Support and system for engineered tissue

Inventors: Erin G. Roberts (Kwun Tong, HK); Eugene K. Lee (Kwun Tong, HK); David D. Tran (Kwun Tong, HK); Suet Yee Mak (Kwun Tong, HK); Bernard Fermini (Kwun Tong, HK); Andy Wong (Kwun Tong, HK)

Assignee: Novoheart International Limited

C12N5/0657 C12M21/08 C12M25/14 C12N2527/00 C12N2533/00 C12N2535/00

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Quick Facts

Patent No.: US 12686852
App. No.: 18/014,897
Granted: Jul 21, 2026
Kind: B2

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Abstract

The present disclosure relates to tissue supports for use with engineered tissues and organoids, such as cardiac organoid chambers. In an embodiment of the present disclosure, the tissue supports are provided with a fluid-impermeable resilient member that is resiliently deformable during testing by cultured tissues formed on the surface of the tissue support.

Claims (18)

1 . A tissue support comprising a fluid-impermeable resilient member having an external surface and defining an enclosed volume;

wherein the external surface of the fluid-impermeable resilient member is resiliently deformable by cultured tissues formed on the external surface of the fluid-impermeable resilient member during testing thereof, and wherein the fluid-impermeable resilient member is retained in place during the testing.

2 . The tissue support of claim 1 , wherein the cultured tissues comprise cardiac cells or cardiac organoids.

3 . The tissue support of claim 1 , wherein the testing is a pressure-volume loop analysis.

4 . The tissue support of claim 1 , wherein the resilient deformation of the external surface of the fluid-impermeable resilient member into the enclosed volume causes a measurable change in the cross sectional area and enclosed volume of the fluid-impermeable resilient member.

5 . The tissue support of claim 1 , wherein the fluid-impermeable resilient member defines a substantially spherical enclosed volume in an inflated state.

6 . The tissue support of claim 5 , wherein the inflation of the fluid-impermeable resilient member allows the enclosed volume to assume a predetermined size and shape.

7 . The tissue support of claim 1 , wherein the fluid-impermeable resilient member has a wall of generally consistent thickness, the thickness between 40-300 μm.

8 . The tissue support of claim 1 , wherein the fluid-impermeable resilient member further comprises an elongate support portion attachable to a fluid loading port.

9 . The tissue support of claim 1 , wherein the cross sectional area of the fluid-impermeable resilient member increases generally linearly relative to loading volume of solutions between a range of 300 to 600 μL into the enclosed volume.

10 . The tissue support of claim 1 , wherein the fluid-impermeable resilient member is formed by a polymeric material with elastic modulus of 1 k Pa-10 MPa.

11 . The tissue support of claim 1 , wherein the external surface of the fluid-impermeable resilient member is provided with one or more topological features to guide biophysical interaction between the tissue and the tissue support.

12 . A tissue support comprising:

a fluid-impermeable resilient member having an external surface and defining an enclosed volume, and a wall of generally consistent thickness between 40-300 μm;

13 . A tissue support comprising:

a fluid-impermeable resilient member having an external surface and defining an enclosed volume having a loading volume between a range of 300 to 600 μL;