IP Library Granted Patent US 12686954
Granted Patent B2
US 12686954 · App. 17/427,895 · Granted Jul 21, 2026

Recombinant-structure protein multifilament and method for manufacturing same

Inventors: Yunosuke Abe (Tsuruoka, JP); Hideto Ishii (Tsuruoka, JP); Ryoko Sato (Tsuruoka, JP); Akito Sato (Tsuruoka, JP); Hirotada Ando (Kariya, JP); Hiroshi Kano (Tsuruoka, JP); Koichi Kotaka (Tsuruoka, JP); Jun Kobayashi (Tsuruoka, JP)
Assignee: CRANE Inc.
D01F4/02C07K14/43518D01D5/06D02G3/045D10B2211/22
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Quick Facts
Patent No.
US 12686954
App. No.
17/427,895
Granted
Jul 21, 2026
Kind
B2
Abstract

An object of the present invention is to provide a method for producing a modified fibroin multifilament excellent in productivity and a multifilament produced by the same. The multifilament of the present invention contains modified fibroin, in which the multifilament has 100 or more constituent single yarns, a coefficient of variation in elastic modulus is 15% or less, a coefficient of variation in strength is 15% or less, and a coefficient of variation in elongation is less than 33%.

Claims (16)

1 . A multifilament comprising modified fibroin, wherein the multifilament has 1,000 or more and 300,000 or less constituent single yarns, a coefficient of variation in elastic modulus of the multifilament is 15% or less, a coefficient of variation in strength of the multifilament is 15% or less, and a coefficient of variation in elongation of the multifilament is 2.6 to 10%.

2 . The multifilament according to claim 1 , wherein a coefficient of variation in fineness of the multifilament is 20% or less.

3 . The multifilament according to claim 1 , wherein the coefficient of variation in strength of the multifilament is 10% or less, and the coefficient of variation in elastic modulus of the multifilament is 10% or less.

4 . The multifilament according to claim 1 , wherein an average hydropathy index of the modified fibroin is more than −0.8.

5 . The multifilament according to claim 1 , wherein the modified fibroin is modified spider silk fibroin.

6 . The multifilament according to claim 1 , wherein the multifilament has a shrinkage history of being irreversibly shrunk after spinning.

7 . The multifilament according to claim 6 , wherein the shrinkage history is a shrinkage history of being irreversibly shrunk by bringing the multifilament into contact with water or a shrinkage history of being irreversibly shrunk by heating and relaxing the multifilament.

8 . The multifilament according to claim 6 , wherein a shrinkage rate of the multifilament having a shrinkage history of being irreversibly shrunk after spinning is 5% or less, the shrinkage rate being defined by the following equation:

Shrinkage rate [%]=(1−(length of multifilament when dried from wet state/length of multifilament when in wet state))×100.

9 . The multifilament according to claim 1 , wherein a coefficient of variation in fineness of the multifilament is 0.01% to 6.5%.

10 . The multifilament according to claim 1 , wherein the coefficient of variation in strength of the multifilament is 0.01% to 3.8%.

11 . A multifilament comprising a recombinant structural protein, wherein the multifilament has 100 or more constituent single yarns, and a coefficient of variation in elongation is 2.6 to 10%.

12 . A method for producing the multifilament of claim 1 , comprising a step of discharging a spinning raw material solution containing modified fibroin and a solvent from a spinning nozzle having 100 or more holes, and bringing the spinning raw material solution into contact with a coagulation liquid to coagulate the modified fibroin.

13 . A method for producing the multifilament of claim 1 , comprising a step of discharging a spinning raw material solution containing a recombinant structural protein and a solvent from a spinning nozzle having 100 or more holes, and bringing the spinning raw material solution into contact with a coagulation liquid to coagulate the recombinant structural protein.

14 . A method for producing the multifilament of claim 11 , comprising a step of discharging a spinning raw material solution containing modified fibroin and a solvent from a spinning nozzle having 100 or more holes, and bringing the spinning raw material solution into contact with a coagulation liquid to coagulate the modified fibroin.

15 . A method for producing the multifilament of claim 11 , comprising a step of discharging a spinning raw material solution containing a recombinant structural protein and a solvent from a spinning nozzle having 100 or more holes, and bringing the spinning raw material solution into contact with a coagulation liquid to coagulate the recombinant structural protein.