Method for three-dimensionally modeling eyeball and optic nerves using merging of MRI images and OCT images

1 . A method for three-dimensionally modeling an eyeball and an optic nerve using a merge of an MRI image and an OCT image, the method comprising:

three-dimensionally modeling an eyeball model based on a shape of the eyeball in a first MRI head image and a second MRI head image;

three-dimensionally modeling an ASCO model in the corrected OCT cross-sectional image of the eyeball;

three-dimensionally modeling a lamina cribrosa (LC) in the corrected OCT cross-sectional image of the eyeball; and

generating an optic nerve model by three-dimensionally modeling an optic nerve path connected to the eyeball model,

wherein the first MRI head image is a first image having a largest eyeball among a plurality of first MRI head images, each of the plurality of first MRI head images being sliced in a XY plane, and

wherein the second MRI head image is a second image having a largest eyeball among a plurality of second MRI head images, each of the plurality of second MRI head images being sliced in a XZ plane,

wherein the three-dimensionally modeling of the eyeball model comprises:

forming a gaze reference line passing through a center of the eyeball and a center of an iris in an MRI head image selected from the first MRI head image and the second MRI head image, the selected MRI head image having a largest inscribed circle inscribed on the eyeball;

forming a plurality of first reference planes perpendicular to the gaze reference line;

forming a plurality of first ellipses on the plurality of first reference planes, respectively, spaced apart from each other.

2 . The method of claim 1 ,

wherein the three-dimensionally modeling of the eyeball model further comprises:

forming an ocular surface surrounding the plurality of first ellipses,

wherein the plurality of first ellipses are asymmetrical ellipses that become smaller toward both sides from a first ellipse located at the center of the eyeball among the plurality of first ellipses, based on an eyeball shape of the plurality of first MRI head images and an eyeball shape of the plurality of second MRI head images.

3 . The method of claim 2 , wherein the three-dimensionally modeling of the eyeball model further comprises:

forming a BMO layer with a thickness of 0.004 mm from an inner surface of the ocular surface;

sequentially forming a choroid and a sclera with a predetermined thickness from an outer surface of the ocular surface; and

generating the eyeball model that is three-dimensionally modeled.

4 . The method of claim 1 ,

wherein the three-dimensionally modeling of the ASCO model comprises:

marking a Bruch's Membrane Opening (BMO), a choroid opening, and an ASCO on the corrected OCT cross-sectional image of the eyeball;

forming a BMO line, a choroid opening line, and an ASCO line to distinguish a Bruch's Membrane Opening (BMO) layer, a choroid opening layer, and an ASCO layer in the corrected OCT cross-sectional image of the eyeball;

forming a normal line perpendicular to the BMO line, the choroid opening line, and the ASCO line and then forming a vertical plane perpendicular to the normal line; and

three-dimensionally modeling the ASCO model by connecting the vertical plane having a penetrated central part with the ASCO line.

5 . The method of claim 1 , wherein the three-dimensionally modeling of the lamina cribrosa comprises:

forming a cross-section of the Lamina Cribrosa (LC) on the corrected OCT cross-sectional image of the eyeball;

forming a second reference plane to form the Lamina Cribrosa (LC); and

three-dimensionally modeling the Lamina Cribrosa (LC) from the second reference plane.

6 . The method of claim 1 ,

wherein the generating of the optic nerve model comprises:

obtaining a center point of an optic nerve root based on the first MRI head image and the second MRI head image;

forming a second connection line connecting the center point of the optic nerve root with a pair of ASCOs; and

forming a plurality of second reference planes dividing the second connection line into five equal parts.

7 . The method of claim 6 , wherein the generating of the optic nerve model further comprises:

forming a plurality of second ellipses on the plurality of second reference planes, respectively, based on the first MRI head image and the second MRI head image;

forming a first reference line connecting centers of the plurality of second ellipses; and

forming an optic nerve path surrounding the plurality of second ellipses along the first reference line.

8 . The method of claim 7 , wherein the generating of the optic nerve model further comprises:

extending an end of the optic nerve path to a sclera;

forming an interior of the optic nerve path by reflecting a preset thickness of the optic nerve path; and

forming a three-dimensionally modeled optic nerve model.

9 . A method for three-dimensionally modeling an eyeball and an optic nerve using a merge of an MRI image and an OCT image, the method comprising:

three-dimensionally modeling an eyeball model based on a shape of the eyeball in a first MRI head image and a second MRI head image;

three-dimensionally modeling an ASCO model in a corrected OCT cross-sectional image of the eyeball;

three-dimensionally modeling a lamina cribrosa (LC) in the corrected OCT cross-sectional image of the eyeball; and

generating an optic nerve model by three-dimensionally modeling an optic nerve path connected to the eyeball model,

wherein the first MRI head image is a first MRI head image having a largest eyeball among a plurality of first MRI head images, each of the plurality of first MRI head images being sliced in a XY plane, and

wherein the second MRI head image is a second MRI head image having a largest eyeball among a plurality of second MRI head images, each of the plurality of second MRI head images being sliced in a XZ plane,

wherein the three-dimensionally modeling of the ASCO model comprises:

marking a Bruch's Membrane Opening (BMO), a choroid opening, and an ASCO on the corrected OCT cross-sectional image of the eyeball;

forming a BMO line, a choroid opening line, and an ASCO line to distinguish a Bruch's Membrane Opening (BMO) layer, a choroid opening layer, and an ASCO layer in the corrected OCT cross-sectional image of the eyeball;

forming a normal line perpendicular to the BMO line, the choroid opening line, and the ASCO line and then forming a vertical plane perpendicular to the normal line; and

three-dimensionally modeling the ASCO model by connecting the vertical plane having a penetrated central part with the ASCO line.

10 . A method for three-dimensionally modeling an eyeball and an optic nerve using a merge of an MRI image and an OCT image, the method comprising:

three-dimensionally modeling an eyeball model based on a shape of the eyeball in a first MRI head image and a second MRI head image;

three-dimensionally modeling an ASCO model in a corrected OCT cross-sectional image of the eyeball;

three-dimensionally modeling a lamina cribrosa (LC) in the corrected OCT cross-sectional image of the eyeball; and

generating an optic nerve model by three-dimensionally modeling an optic nerve path connected to the eyeball model,

wherein the first MRI head image is a first MRI head image having a largest eyeball among a plurality of first MRI head images, each of the plurality of first MRI head images being sliced in a XY plane, and

wherein the second MRI head image is a second MRI head image having a largest eyeball among a plurality of second MRI head images, each of the plurality of second MRI head images being sliced in a XZ plane,

wherein the generating of the optic nerve model comprises:

obtaining a center point of an optic nerve root based on the first MRI head image and the second MRI head image;

forming a second connection line connecting the center point of the optic nerve root with a pair of ASCOs; and

forming a plurality of second reference planes dividing the second connection line into five equal parts.