IP Library Granted Patent US 12688909
Granted Patent B2
US 12688909 · App. 18/778,042 · Granted Jul 21, 2026

System and methods for upsampling of decompressed genomic data after lossy compression using a neural network

Inventors: Zhu Li (Overland Park, KS); Brian Galvin (Silverdale, WA); Paras Maharjan (Kansas City, MO)
Assignee: ATOMBEAM TECHNOLOGIES INC.
G16B50/50G06N3/0464G06N3/048H03M7/3059H03M7/70
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Quick Facts
Patent No.
US 12688909
App. No.
18/778,042
Granted
Jul 21, 2026
Kind
B2
Abstract

A system and methods for upsampling of decompressed biological data after lossy compression using a neural network integrates AI-based techniques to enhance compression quality. It incorporates a novel deep-learning neural network that upsamples decompressed data to restore information lost during lossy compression, taking advantage of cross-correlations between biological data sets.

Claims (22)

1 . A system for upsampling of decompressed biological data after lossy compression using a neural network, comprising:

a computing system comprising at least a memory and a processor;

two or more datasets that are substantially correlated and which have been compressed with lossy compression, the two or more datasets comprising biological data;

a deep learning neural network configured to recover lost information associated with a compressed bit stream; and

a decoder comprising a first plurality of programming instructions that, when operating on the processor, cause the computing system to:

receive a compressed bit stream, the compressed bit stream comprising cross-correlated biological data;

decompress each of the compressed bit stream; and

use the decompressed bit stream as an input into the deep learning neural network to recover lost information associated with the biological data.

2 . The system of claim 1 , wherein the biological data comprises parallel biological datasets.

3 . The system of claim 1 , wherein the two or more datasets comprise genomic data from a subset of the human genome.

4 . The system of claim 1 , wherein the deep learning neural network is a neural network that can recover signals from a compressed bitstream.

5 . The system of claim 1 , wherein the compressed bit stream comprises a plurality of channels, wherein each of the plurality of channels is associated with a genomic dataset.

6 . A method for upsampling of decompressed biological data after lossy compression using a neural network, comprising the steps of:

training a deep learning neural network to recover lost information associated with a compressed bit stream;

receiving the compressed bit stream, the compressed bit stream comprising cross-correlated biological data;

decompressing the compressed bit stream; and

using the decompressed bit stream as an input into the deep learning neural network to recover information lost during lossy compression of the biological data.

7 . The method of claim 6 , wherein the biological data comprises parallel biological datasets.

8 . The method of claim 6 , wherein the two or more datasets comprise genomic data from a subset of the human genome.

9 . The method of claim 6 , wherein the deep learning neural network is a neural network that can recover signals from a compressed bitstream.

10 . The method of claim 6 , wherein the compressed bit stream comprises a plurality of channels, wherein each of the plurality of channels is associated with a genomic dataset.

11 . One or more non-transitory computer-storage media having computer-executable instructions embodied thereon that, when executed by one or more processors of a computing system employing a neural upsampler configured for biological data, cause the computing system to perform the method of claim 6 .