Smart contact lens for ultrasensitive diabetes diagnosis
The present disclosure relates to a smart contact lens for diabetes diagnosis in which a diabetic diagnosis sensor is composed of platinum-plated electrodes, and a driving system using the same. The smart contact lens of the present disclosure is easy to mass-produce, has good wireless power transfer efficiency due to high electrical conductivity, may perform good communication with an external driving board, and may perform physically and electrochemically stable driving.
1 . A smart contact lens for diabetes diagnosis, comprising:
a platinum-plated electrode including an electrically conductive layer and a reaction layer; and
a porous hydrogel including a nanocatalyst,
wherein the reaction layer includes platinum (Pt),
wherein the nanocatalyst comprises gold-platinum bimetallic nanoparticles with thiolated hyaluronic acid, and
wherein the porous hydrogel is prepared through:
preparing a base solution comprising polyvinyl alcohol (PVA), chitosan, bovine serum albumin (BSA), and glucose oxidase (GOx);
adding magnesium particles and the nanocatalyst to the base solution to prepare a mixture, drop casting and drying the mixture;
drop casting a solution comprising a glutaraldehyde and crosslinking the mixture; and
removing the magnesium particles.
2 . The smart contact lens of claim 1 , wherein the electrically conductive layer includes copper (Cu).
3 . The smart contact lens of claim 1 , wherein the platinum-plated electrode is used as one or more of a working electrode and a counter electrode.
4 . The smart contact lens of claim 1 , wherein:
the platinum-plated electrode is formed on a flexible substrate; and
the flexible substrate includes one or more selected from the group consisting of polyimide (PI), colorless PI (CPI), polyethylene naphthalate (PEN), and polycarbonate (PC).
5 . The smart contact lens of claim 1 , wherein:
the platinum-plated electrode is surface-treated with a first biocompatible polymer; and
the first biocompatible polymer includes one or more selected from the group consisting of polyethylene glycol, polylactic acid, polyglycolic acid, polylactic glycolic acid, polyvinylpyrrolidone, hyaluronic acid (HA) and a derivative thereof.
6 . The smart contact lens of claim 1 , wherein the platinum-plated electrode is manufactured through:
an operation of transferring an electrically conductive layer onto a flexible substrate;
an operation of plating an intermediate layer on the electrically conductive layer;
an operation of plating a reaction layer on the intermediate layer; and
an operation of surface-treating the reaction layer with a first biocompatible polymer.
7 . The smart contact lens of claim 1 , wherein the porous hydrogel including the nanocatalyst is formed on a working electrode.
8 . A driving system of a smart contact lens comprising:
the smart contact lens for diabetes diagnosis according to claim 1 ; and
a wireless controller for driving the smart contact lens for diabetic diagnosis.
9 . The driving system of claim 8 , wherein the wireless controller ( 100 ) includes:
a power unit to which power is input;
a battery unit ( 101 ) in which a battery is charged;
a system manager ( 102 ) for controlling the entire device;
a radio-frequency (RF) power transmission unit ( 105 ) for wireless power transmission;
an antenna ( 108 ) and an RF signal discrimination unit ( 117 ) for sensing a sensor signal of the smart contact lens; and
a Bluetooth antenna ( 126 ) for Bluetooth communication.