Methods and systems for the detection of disease
Disclosed herein are systems and methods for the detection of neurological condition in a subject. The disclosed methods and systems provide, in certain embodiments, providing optical stimuli to a subject via a graphical display, capturing, using a camera, a plurality of images of eyes of the subject when the optical stimuli is provided to the subject via the graphical display, determining, by a processor, an occurrence of one or more ocular responses of structures of the eyes based on the plurality of images, identifying, by the processor, an occurrence of a neurological condition in the subject based on the one or more ocular responses, and providing the identification of the occurrence of the neurological condition to the subject via a graphical user interface.
1 . A method comprising:
providing optical stimuli to a subject via a graphical display;
capturing, using a camera, a plurality of images of eyes of the subject when the optical stimuli is provided to the subject via the graphical display;
determining, by a processor and based on the plurality of images, an occurrence of a first ocular response of at least one structure of the eyes, the first ocular response including a displacement of a boundary of the at least one structure of the eyes across successive images;
identifying, by the processor, an occurrence of a neurological condition in the subject based on a difference between the first ocular response and a predefined ocular response of the at least one structure of the eyes; and
providing the identification of the occurrence of the neurological condition to the subject via a graphical user interface.
2 . The method of claim 1 , wherein providing the optical stimuli to the subject comprises moving the optical stimuli on the graphical display.
3 . The method of claim 2 , wherein the first ocular response comprises a change in an ability of the subject to track the moving optical stimuli presented via the graphical display.
4 . The method of claim 1 , wherein the at least one structure of the eyes comprise at least one of a retina, blood vessels in the retina, an iris, and a pupil.
5 . The method of claim 4 , wherein the first ocular response comprises a dilation of the pupil in response to the optical stimuli.
6 . The method of claim 4 , wherein the determining of the first ocular response comprises detecting a change in diameters of the blood vessels in the retina between two time points.
7 . The method of claim 1 , wherein the determining of the the first ocular response comprises detecting a change in movement speed of the structures of the eyes between two time points.
8 . The method of claim 1 , wherein the determining of the first ocular response comprises:
comparing a coordination of movement between the at least one structure of the eyes of the subject in response to the optical stimuli; and
detecting a time difference in movement of the at least one structure of the eyes of the subject based on the comparison.
9 . The method of claim 1 , wherein the determining of the first ocular response comprises comparing the plurality of images with a baseline recording.
10 . The method of claim 1 , wherein the neurological condition comprises at least one of a concussion, a type 1 diabetes, a type 2 diabetes, an Alzheimer's disease, and a condition associated with altered brain metabolism.
11 . The method of claim 1 , wherein identifying the neurological condition comprises identifying changes in neurotransmission and/or alterations in physiological markers.
12 . A system comprising:
a graphical display configured to present optical stimuli to the subject, wherein the optical stimuli are configured to induce eye movements of the subject;
a camera configured to capture a plurality of images of the eyes of the subject when the optical stimuli is presented to the subject via the graphical display;
a processor communicatively coupled to the generator, the graphical display, and the camera; and
non-transitory memory storing instructions, which, when executed by the processor causes the processor to perform operations comprising:
generating the optical stimuli for presentation on the graphical display;
receiving, from the camera, data characterizing the plurality of images;
determining, based on the plurality of images an occurrence of a first ocular response of at least one structure of the eyes, the first ocular response including a displacement of a boundary of the at least one structure of the eyes across successive images;
identifying an occurrence of a neurometabolic condition in the subject based on a difference between the first ocular response and a predefined ocular response of the at least one structure of the eyes; and
displaying the identification of the occurrence of the neurometabolic condition to the subject via a graphical user interface.
13 . The system of claim 12 , wherein presenting the optical stimuli to the subject comprises moving the optical stimuli on the graphical display.
14 . The system of claim 12 wherein the at least one structure of the eyes comprise at least one of a retina, blood vessels in the retina, an iris, and a pupil.
15 . The system of claim 14 , wherein the first ocular response comprises a dilation of the pupil in response to the optical stimuli.
16 . The system of claim 14 , wherein the determining of the first ocular response comprises detecting a change in diameters of the blood vessels in the retina between two time points.
17 . The system of claim 12 , wherein the determining of the first ocular response comprises detecting a change in movement speed of the structures of the eyes between two time points.
18 . The system of claim 12 , wherein the determining of the first ocular response comprises:
comparing a coordination of movement between the at least one structure of the eyes of the subject in response to the optical stimuli; and
detecting a time difference in movement of the at least one structure of the eyes of the subject based on the comparison.
19 . The System of claim 12 , wherein the determining of the first ocular response comprises comparing the plurality of images with a baseline recording.