Therapeutic treatment device with inverted braided vessel occluder
An endovascular treatment device for use in a vessel during a therapy procedure includes a catheter and a vessel occluder coupled to the catheter. The occluder includes a construction of elastic filaments that are fixed to the outer surface of the catheter. The filaments extend radially and distally outward from their proximal ends and then invert and are fixed back at the catheter proximal of the distal end of the catheter. The occluder can be elastically deformed to fit vessels of various sizes. The catheter includes a lumen through which a therapeutic agent is delivered beyond the occluder.
1 . An endovascular therapeutic device for delivery of a therapeutic agent within a vessel of a human patient during an intravascular procedure, the vessel having a vessel wall, comprising:
a) a flexible catheter sized for introduction into the vessel, the flexible catheter having a proximal end and a distal end, an outer surface, a lumen extending between the proximal and distal ends and an opening at a distal orifice; and
b) a filter valve mounted on the outer surface of the flexible catheter adjacent the distal end of the flexible catheter, the filter valve comprising:
i) a filamentary construct comprising a plurality of elastic filamentary strands, each of the elastic filamentary strands having a proximal portion, a central portion, and a distal portion, the proximal portions of the plurality of elastic filamentary strands longitudinally fixed to the outer surface of the catheter at a first location proximal of the orifice, the central portions of the plurality of elastic filamentary strands extending from the proximal portion distally toward the orifice and having shape memory to extend radially outward from the outer surface, and the distal portions of the plurality of elastic filamentary strands inverting proximally to the outer surface of the catheter, the distal portions of the plurality of elastic filamentary strands longitudinally fixed to the outer surface of the catheter, and
ii) a polymeric material coating a proximal portion of the filamentary construct across the plurality of elastic filamentary strands, the polymeric material forming a barrier to passage of the therapeutic agent, and wherein a distal portion of the filamentary construct is uncoated.
2 . The therapeutic device of claim 1 , wherein the plurality of elastic filamentary strands are braided together.
3 . The therapeutic device of claim 1 , wherein the plurality of elastic filamentary strands are independently movable relative to each other between their proximal and distal ends.
4 . The therapeutic device of claim 1 , wherein the plurality of elastic filamentary strands are made of nitinol.
5 . The therapeutic device of claim 1 , wherein the polymeric material is coating the proximal portion and a central portion of the filamentary construct across the plurality of elastic filamentary strands.
6 . The therapeutic device of claim 1 , wherein the polymeric material is electrospun onto at least a portion of the filamentary construct.
7 . The therapeutic device of claim 1 , wherein the polymeric material extends between and across the proximal portions of the plurality of elastic filamentary strands.
8 . The therapeutic device of claim 1 , wherein the polymeric material comprises polyurethane.
9 . The therapeutic device of claim 1 , wherein at least a portion of the polymeric material is fluid impermeable.
10 . The therapeutic device of claim 1 , wherein the therapeutic agent is a particulate embolic agent, and at least a portion of the polymeric material is porous.
11 . The therapeutic device of claim 1 , wherein the distal portions of the plurality of elastic filamentary strands are fixed to the outer surface of the catheter.
12 . The therapeutic device of claim 1 , wherein the distal portions of the plurality of elastic filamentary strands are movably retained about the outer surface of the catheter.
13 . The device of claim 1 , wherein the filter valve dynamically changes configuration in response to the fluid pressure conditions about a proximal portion and a distal portion of the filter valve.
14 . The device of claim 1 , wherein the distal portions of the plurality of elastic filamentary strands are longitudinally fixed to the outer surface of the catheter at a second location proximal of the orifice, wherein the second location is distal to the first location.
15 . An endovascular therapeutic device for delivery of a therapeutic agent within a vessel of a human patient during an intravascular procedure, the vessel having a vessel wall, comprising:
a) a flexible catheter sized for introduction into the vessel, the flexible catheter having a proximal end and a distal end, an outer surface, a lumen extending between the proximal and distal ends and an opening at a distal orifice; and
b) a braided construct comprising a plurality of elastic filamentary strands mounted on the outer surface of the flexible catheter, each of the plurality of elastic filamentary strands having a proximal portion, a central portion, and a distal portion, the proximal portions of the plurality of elastic filamentary strands longitudinally fixed to the outer surface of the catheter at a first location proximal of the orifice, the central portions of the plurality of elastic filamentary strands extending from the proximal portion distally toward the orifice and having shape memory to extend radially outward from the outer surface, and the distal portions of the plurality of elastic filamentary strands inverting proximally to the outer surface of the catheter, the distal portions of the plurality of elastic filamentary strands longitudinally fixed relative to the outer surface of the catheter, and
a proximal portion of the braided construct coated in a polymer coating that functions as a barrier to passage of the therapeutic agent and a distal portion of the braided construct is uncoated.
16 . The device of claim 15 , wherein the polymer coating comprises polyurethane.
17 . The device of claim 15 , wherein the polymer coating is a web of electrostatically deposited polymer filaments.
18 . The device of claim 15 , wherein the plurality of elastic filamentary strands are made of nitinol.
19 . The device of claim 15 , wherein a distal portion of the braided construct has greater fluid permeability than the proximal portion of the braided construct.
20 . The device of claim 1 , wherein the therapeutic agent is selected from the group consisting of an embolizing agent, a chemotherapy agent, an immunotherapy agent, and a radiation agent.
21 . The device of claim 20 , wherein the therapeutic agent is the embolizing agent.
22 . The device of claim 20 , wherein the therapeutic agent is the immunotherapy agent.
23 . The device of claim 22 , wherein the immunotherapy agent is selected from the group consisting of an immunomodulator, a vaccine, a modified cell, and a check-point inhibitor.
24 . The device of claim 23 , wherein the immunotherapy agent is the immunomodulator.
25 . The device of claim 23 , wherein the immunotherapy agent is the check-point inhibitor.
26 . The device of claim 15 , wherein the therapeutic agent is selected from the group consisting of an embolizing agent, a chemotherapy agent, an immunotherapy agent, and a radiation agent.
27 . The device of claim 26 , wherein the therapeutic agent is the embolizing agent.
28 . The device of claim 26 , wherein the therapeutic agent is the immunotherapy agent.
29 . The device of claim 28 , wherein the immunotherapy agent is selected from the group consisting of an immunomodulator, a vaccine, a modified cell, and a check-point inhibitor.
30 . The device of claim 29 , wherein the immunotherapy agent is the immunomodulator.
31 . The device of claim 29 , wherein the immunotherapy agent is the check-point inhibitor.
32 . The device of claim 15 , wherein the braided construct dynamically changes configuration in response to the fluid pressure conditions about the proximal portion and a distal portion of the braided construct.
33 . The device of claim 15 , wherein the distal portions of the plurality of elastic filamentary strands are longitudinally fixed to the outer surface of the catheter at a second location proximal of the orifice, wherein the second location is distal to the first location.