Automated drug filling process

1 . An automatic drug substance (DS) fill system, comprising:

a plurality of pumps, each pump configured to fill a respective DS container of a plurality of DS containers;

a plurality of weighing scales, each weighing scale configured to measure weights associated with each respective DS container of the plurality of DS containers; and

a controller configured to:

cause each of the plurality of pumps to simultaneously fill each respective DS container, of the plurality of DS containers;

monitor the weights associated with each respective DS container of the plurality of DS containers measured by each of the plurality of weighing scales;

compare the weights associated with each respective DS container, of the plurality of DS containers measured by each of the plurality of weighing scales, to a threshold weight; and

independently control each pump of the plurality of pumps to cease filling each respective DS container based on the weight measured by the weighing scale associated with a respective pump's respective DS container reaching the threshold weight.

2 . The automatic DS fill system of claim 1 , further comprising a tubing manifold configured to connect a fill line from a DS source to each of the plurality of pumps via a sealed, sterile connection.

3 . The automatic DS fill system of claim 1 , further comprising a user interface, and wherein the controller is further configured to receive an indication of the threshold weight as an input via the user interface.

4 . The automatic DS fill system of claim 1 , wherein the controller is further configured to generate respective alerts based on the weight associated with each DS container reaching the threshold weight.

5 . An automatic drug substance (DS) fill system, comprising:

a plurality of pumps, each pump configured to fill a respective DS container of a plurality of DS containers;

a tubing manifold configured to connect a fill line from a DS source to each of the plurality of pumps via a sealed, sterile connection;

a plurality of sensors, each sensor configured to measure a volume of a DS flowing from each of the plurality of pumps into each respective DS container of the plurality of DS containers; and

a controller configured to:

cause each of the plurality of pumps to simultaneously fill each respective DS container, of the plurality of DS containers;

monitor the fill volume from each of the plurality of pumps into each respective DS container into the plurality of DS containers;

compare the fill volume associated with each respective DS container, of the plurality of DS containers, measured by each of the sensors, to a threshold volume; and

independently control each pump of the plurality of pumps to cease filling based on the fill volume measured by the sensor associated with a respective pump's respective DS container reaching the threshold volume.

6 . The automatic DS fill system of claim 5 , wherein the sensor is a pump-head rotation sensor.

7 . The automatic DS fill system of claim 5 , further comprising a user interface, and wherein the controller is further configured to receive an indication of the threshold volume as an input via the user interface.

8 . The automatic DS fill system of claim 5 wherein the controller is further configured to generate respective alerts based on the fill volume associated with each DS container reaching the threshold volume.

9 . An automatic drug substance (DS) fill method, comprising:

causing, by a controller, each of a plurality of pumps to simultaneously fill each a respective DS container, of a plurality of DS containers;

monitoring, by a plurality of sensors, each sensor associated with a respective DS container of the plurality of DS containers, fill volumes associated with each respective DS container;

comparing, by the controller, the fill volumes associated with each respective DS container, of the plurality of DS containers measured by each of the plurality of sensors to a threshold volume; and

independently controlling, by the controller, each pump of the plurality of pumps to cease filling each respective DS container based on the fill volume measured for a respective pump's respective DS container reaching the threshold volume.

10 . The automatic DS fill method of claim 9 , wherein the plurality of sensors are pump-head rotation sensors.

11 . The automatic DS fill method of claim 9 , further comprising: receiving, by the controller, an indication of the threshold volume as an input via a user interface.

12 . The automatic DS fill method of claim 9 , further comprising, generating, by the controller, respective alerts based on the fill volume associated with each DS container reaching the threshold volume.