Dual-targeting biomimetic liposome with elemene (ELE) and cabazitaxel (CTX), and preparation method and use thereof
The present disclosure provides a dual-targeting biomimetic liposome with elemene (ELE) and cabazitaxel (CTX), where each 100 mL of the dual-targeting biomimetic liposome with ELE and CTX includes 0.15 g to 0.75 g of the ELE, 0.5 mL to 2.5 mL of absolute ethanol, 0.015 g to 0.07 g of the CTX, 0.25 g to 1 g of oil, 0.25 g to 1 g of a polyethylene glycol (PEG) derivative, 1 g to 5 g of a phospholipid, 0.05 g to 0.2 g of cholesterol, 0.025 g to 0.1 g of distearoyl phosphatidylethanolamine-polyethylene glycol 2000-transferrin (DSPE-PEG2000-Tf), 0.005 g to 0.025 g of a tumor cell membrane protein (CMP), and water as a balance.
1 . A dual-targeting biomimetic liposome with elemene (ELE) and cabazitaxel (CTX), wherein each 100 mL of the dual-targeting biomimetic liposome with ELE and CTX comprises 0.15 g to 0.75 g of the ELE, 0.5 mL to 2.5 mL of absolute ethanol, 0.015 g to 0.07 g of the CTX, 0.25 g to 1 g of oil, 0.25 g to 1 g of a polyethylene glycol (PEG) derivative, 1 g to 5 g of a phospholipid, 0.05 g to 0.2 g of cholesterol, 0.025 g to 0.1 g of distearoyl phosphatidylethanolamine-polyethylene glycol-transferrin (DSPE-PEG-Tf), 0.005 g to 0.025 g of a tumor cell membrane protein (CMP), and water as a balance.
2 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , wherein the oil is one or more selected from the group consisting of medium-chain triglyceride (MCT), soybean oil, palm oil, coconut oil, fish oil, hydrogenated oil, and animal oil.
3 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , wherein the phospholipid is one or more selected from the group consisting of soybean phospholipid, egg yolk phospholipid, hydrogenated phospholipid, and synthetic phospholipid.
4 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , wherein the PEG derivative is selected from the group consisting of D-α-tocopherol polyethylene glycol succinate (TPGS) and DSPE-PEG.
5 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , wherein the DSPE-PEG-Tf is selected from the group consisting of DSPE-PEG2000-Tf, DSPE-PEG3000-Tf, DSPE-PEG4000-Tf, and DSPE-PEG5000-Tf.
6 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , further comprising an osmotic pressure regulator.
7 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 6 , wherein the osmotic pressure regulator is one or more selected from the group consisting of glycerol, glucose, sucrose, trehalose, maltose, and mannitol.
8 . The dual-targeting biomimetic liposome with ELE and CTX according to claim 1 , wherein the ELE and the CTX are at a mass ratio of 10:1.