Modular lipid compounds and two- to three-component lipid nanoparticle compositions
Novel delivery nanoparticles composes of two-, or three-component lipid compounds. Compositions comprising such lipid compounds, and related methods of their use are disclosed. Nanoparticle compositions include at least one novel modular lipid as well as additional lipids such as ionizable lipids, and phospholipids. Nanoparticle compositions further including biologically active agents, such as siRNA or mRNA, are useful in the delivery of said biologically active agents to subjects in need thereof.
1 . A modular lipid selected from:
2 . A compound selected from:
3 . The lipid of claim 2 , selected from P380D1, P380E1, P380F1, P380F4, and P381F1.
4 . The lipid of claim 2 , selected from P429D1.
5 . The lipid of claim 2 , selected from P374F7, P376F1, and P386D12.
6 . The lipid of claim 2 , selected from P423A2 and P423C7.
7 . The lipid of claim 2 , selected from P390E12.
8 . The lipid of claim 2 , selected from P160B4, P160E6, P161C4, P161E4, P161E6, P161F4, P161F5, P169A2, and P177F6.
9 . The lipid of claim 2 , selected from P287A6, P287C4, P287C6, P287F4, P287F6, and P294A6.
10 . The lipid of claim 2 , selected from P320E7, P345E7, and P345G7.
11 . The lipid of claim 2 , selected from P169A8, P169C10, P169C12, and P169F10.
12 . The lipid of claim 2 , selected from P287A10, P287B10, P287B12, P287C10, P287D10, and P287F10.
13 . The lipid of claim 2 , selected from P165A10, P165D10, P165E12, P165F10, and P173F10.
14 . The lipid of claim 2 , wherein the lipid is P171D12.