Stable compositions of functional ingredients and methods of making the same
Provided is a composition, including: an aqueous suspension, comprising: a first plurality of active ingredients, and one or more nanoparticles, wherein: the one or more nanoparticles encapsulate a second plurality of active ingredients; the second plurality of active ingredients are insoluble in the aqueous suspension; the one or more nanoparticles solubilize the second plurality of active ingredients in the aqueous suspension; and the one or more nanoparticles have a Z-average diameter between 50 to 950 nanometers.
1 . A composition for oral consumption, comprising:
an aqueous suspension, comprising:
a first plurality of active ingredients, wherein:
the first plurality of active ingredients are soluble in the aqueous suspension; and
one or more nanoparticles, wherein:
the one or more nanoparticles encapsulate a second plurality of active ingredients;
the second plurality of active ingredients are insoluble in the aqueous suspension;
the one or more nanoparticles solubilize the second plurality of active ingredients in the aqueous suspension;
the one or more nanoparticles have a Z-average diameter between 50 to 950 nanometers;
the Z-average diameter of the one or more nanoparticles changes less than 20% when the aqueous suspension is incubated at 40° C. for four weeks;
the one or more nanoparticles has a charge that is larger than 15 mV;
the one or more nanoparticles comprise a crosslinked hydrophilic polymer network at an interface of the one or more nanoparticles; and
the Z-average diameter of the one or more nanoparticles changes less than 20% when the aqueous suspension is incubated at 90° C. for 30 minutes.
2 . The composition of claim 1 , wherein:
the second plurality of active ingredients is selected from the group consisting of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Acmella oleracea, Helichrysum umbraculigerum, Radula marginata, kava, kanna , black truffle, Syzygium aromaticum, Rosmarinus oficinalis, Sceletium tortuosum , Holy basil, Oregano, Lavender, Cinnamon, Malabathrum, Cananga odorata, Ginkgo biloba, Bacopa , and Rhodiola rosea , Ashwagandha, Astragalus, Chaga, Cordyceps, Corydalis , Curcumin, Damiana, Eleuthero, Ginger root, Ginseng , Gotu Kola, Lion's Mane, Maca, Passionflower, Saffron, Schisandra, St. John's Wort, Turmeric, Turkey Tail, Valerian root, Yohimbe, or combinations thereof.
3 . The composition of claim 1 , wherein:
the second plurality of active ingredients is selected from the group consisting of cannabidiol, cannabichromene, cannabigerol, cannabicyclol, cannabinol, cannabigerolic acid, cannabigerolic acid monomethylether, cannabigerol monomethyl ether, cannabichromanon, cannabichromenic acid, cannabichromevarin, cannabichromevarinic acid, tetrahydrocannabinol, iso-tetrahydrocannabinol, cannabinol methylether, cannabinol-C4, cannabinol-C2, cannabiorcol, cannabinodiol, cannabielsoin, cannabielsoic acid A, cannabielsoic acid B, cannabicyclol, cannabicyclolic acid, cannabicyclovarin, cannabicitran, cannabitriol, cannabitriolvarin, ethoxy-cannabitiolvarin, cannabivarin, cannabinodivarin, tetrahydrocannabivarin, cannabidivarin, cannabigerovarin, cannabigerovarinic acid, cannabifuran, dehydrocannabifuran, cannabiripsol cannabinoids, or combinations thereof.
4 . The composition of claim 1 , wherein the composition is a beverage, a gum, or a food snack.
5 . The composition of claim 1 , wherein the one or more nanoparticles further comprising:
a plurality of emulsifying agents selected from the group consisting of an extract of Quillaja, extract of Licorice, polysorbate 20, polysorbate 40, polysorbate 45, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 81 and polysorbate 85, polyglyceryl, gum acacia, Polyglycerol polyricinoleate, sorbitan 85, sorbitan 65, sorbitan 83, sorbitan 80, sorbitan 60, sorbitan 40, Xanthan gum, sorbitol, mannitol, glycerol, sodium alginate, lecithin, chemically modified lecithin, purified components of lecithin, phosphatidylcholine, phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingomyelin, and cardiolipin, hydrogenated soybean phosphatidylcholine, hydrogenated soybean phosphatidylcholine, tocopherol polyethylene glycol succinate, fatty acid mono-and di-glycerides, acetic acid esters of mono-and di-glycerides, lactic acid esters of mono-and di-glycerides, citric acid esters of mono-and di-glycerides, diacetyl tartaric acid ester of mono-and di-glycerides, triglycerol monooleate, hexaglycerol octasterate, polyglycerol esters of oleic acid, decaglycerol mono-and di-oleate, glyceryl caprylate, glyceryl caprate, glyceryl caprate/caprylate, glyceryl monooleate, glycerly monostearate, poloxamers, milk proteins, casein, pea proteins, whey proteins, collagen, sodium stearoyl lactylate, extract of bacopa, withaferin A, withaferin B, withanolide A, withanolide B, withanolide C, withanolide D, withanolide E, withanolide F, withanolide G, withanoside I, withanoside II, withanoside III, withanoside IV, withanoside V, withanoside VI, withanoside VII, bacopaside I, bacopaside II, bacopaside III, bacopaside IV, bacopaside V, bacopaside VI, bacopaside VII, bacopaside VIII, bacopaside IX, bacopaside X, bacopaside XI, bacopaside XII, bacopaside N1, bacopaside N2, bacosaponin A, bacosaponin B, bacosaponin C, bacosaponin D, bacosaponin E, bacosaponin F, bacosaponin G, bacosaponin H, bacoside A3, bacosine, or combinations thereof.
6 . The composition of claim 1 , wherein the aqueous suspension further comprising:
a first polymer selected from the group consisting of alginic acid, gum Arabic, locust bean gum, sodium alginate, potassium alginate, calcium alginate, agar, guar gum, and xanthan gum.
7 . The composition of claim 1 , wherein the one or more nanoparticles further comprising:
a dispersed phase comprising:
a third plurality of active ingredients; and
a second polymer.
8 . The composition of claim 7 , wherein:
the third plurality of active ingredients is selected from the group consisting of methylphenidate, dextroamphetamine, amphetamine, Caffeine, nicotine, Methamphetamine, 3,4-Methylenedioxymethamphetamine, Methylenedioxypyrovalerone, Mephedrone, Phenylpropanolamine, Propylhexedrine, Pseudoephedrine, Catha edulis , Modafinil, xanthines, theophylline, and theobromine, or combinations thereof.
9 . The composition of claim 7 , wherein:
the second polymer is selected from the group consisting of alginic acid, gum Arabic, locust bean gum, sodium alginate, potassium alginate, calcium alginate, agar, guar gum, and xanthan gum.
10 . The composition of claim 1 , wherein the one or more nanoparticles further comprising:
a first polymer selected from the group consisting of methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, shellac, ethyl methyl cellulose, carboxymethyl cellulose, ethyl cellulose, microcrystalline cellulose, cellulose, 12-hydroxystearic acid, and a combination thereof.
11 . The composition of claim 10 , wherein the first polymer retards the release of the second plurality of active ingredients after consumption.
12 . The composition of claim 1 , wherein the one or more nanoparticles has a net negative charge that is −15 mV or lower.
13 . The composition of claim 12 , wherein the net negative charge of the one or more nanoparticles causes the one or more nanoparticles to repel each other with a force of repulsion that leads to stable dispersion of the one or more nanoparticles when the first composition is diluted at least up to 10 fold with an aqueous fluid.
14 . The composition of claim 1 , wherein the one or more nanoparticles has a net positive charge that is +15 mV or higher.
15 . The composition of claim 14 , wherein the net positive charge is mainly generated by a plurality of emulsifying agents, associated with the one or more nanoparticles, selected from the group consisting of Ethyl lauroyl arginate, dialkyl ammonium chloride, monoalkyl ammonium chloride, chitosan, n-dodecyl dimethyl benzyl ammonium chloride, n-dodecyl dimethyl ethylbenzyl ammonium chloride, n-hexadecyl dimethyl benzyl ammonium chloride, n-octadecyl dimethyl benzyl ammonium chloride, n-tetradecyl dimethyl benzyl ammonium chloride, n-tetradecyl dimethyl ethylbenzyl ammonium chloride, and a combination thereof.
16 . The composition of claim 1 , wherein size, polydispersity, and force of repulsion of the one or more nanoparticles produce a bloom effect, wherein the bloom effect of the one or more nanoparticles prevents sublimation of ice crystals from a surface of a substrate, thereby preventing freezer burn of the composition.
17 . The composition of claim 1 , wherein the one or more nanoparticles are 0.01 wt % to 70 wt % of the composition.
18 . The composition of claim 1 , wherein the one or more nanoparticles further comprises a bioenhancer ingredient selected from the group consisting of aloin A, aloin B, emodin, 2-gingerol, 4-gingerol, 6-gingerol, 8-gingerol, 10-gingerol, 12-gingerol, 6-shogaol, 10-shogaol, 6-paradol, Niazirin, niaziridin, bergamottin, genistein, isoquercetin, isorhamnetin, kaempferol, naringin, naringinin, nobiletin, quercetin, quercitrin, tangeritin, rutin, tamarixetin 6′,7′-dihydroxybergamottin, resveratrol, trans-resveratro, cis-resveratrol, luteolin, luteolin-7-O-glucoside, stevioside, steviol, rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, stigmasterol, stigmasterol-3-O-beta-d-glucoside, beta-sitosterol, caffeic acid, chicoric acid, cinnamic acid, chlorogenic acid, gallic acid, green tea, catechin, catechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate, sodium and potassium salts of cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, taurodeoxycholic acid, glycodeoxycholic acid, tauroursodeoxycholic acid, glycoursodeoxycholic, lithocholic acid, or combinations thereof.
19 . The composition of claim 1 , wherein the composition further comprises a bioenhancer ingredient selected from the group consisting of Allicin, Capsaicinoids, Homocapsaicin, dihydrocapsaicin, homodihydrocapsaicin, noredihydrocapsaicin, nonivamide, capsaicin, alkaloids, berberine, bidesmethoxycurcumin, curcumin, desmethoxycurcumin, lysergol, piperine, piperidine, sinomenine, terpenes, terpenoids, 1-8 cineole, bergamotene, carvacrol, carvone, caryophyllene, elemene, eugenol, farnesene, geraniol, glycyrrhizin, humulene, kaurene, limonene, pinene, sterebin A, sterebin B, sterebin C, sterebin D, sterebin E, sterebin F, sterebin G, sterebin H, terpinen-4-ol, gamma-terpinene, alpha-terpineol, terpinolene, kavalactones, methysticin, dihydromethysticin, yangonin, desmethoxyyangonin, kavain, and dihydrokavain, alpha-boswellic acid, beta-boswellic acid, bile acid acids, cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, taurodeoxycholic acid, glycodeoxycholic acid, tauroursodeoxycholic acid, glycoursodeoxycholic, lithocholic acid, GRAS triglycerides, diglycerides, and monoglycerides, or combinations thereof.
20 . A composition for oral consumption, comprising:
an aqueous suspension, comprising:
a first plurality of active ingredients selected from the group consisting of methylphenidate, dextroamphetamine, amphetamine, dextroamphetamine, Caffeine, nicotine, Methamphetamine, 3,4-Methylenedioxymethamphetamine, Methylenedioxypyrovalerone, Mephedrone, Phenylpropanolamine, Propylhexedrine, Pseudoephedrine, Catha edulis , Modafinil, xanthine derivatives, theophylline, and theobromine, wherein:
the first plurality of active ingredients are soluble in the aqueous suspension; and
one or more nanoparticles, wherein:
the one or more nanoparticles encapsulate a second plurality of active ingredient selected from the group consisting of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Acmella oleracea, Helichrysum umbraculigerum, Radula marginata, kava, kanna , black truffle, Syzygium aromaticum, Rosmarinus oficinalis, Sceletium tortuosum , Holy basil, Oregano, Lavender, Cinnamon, Malabathrum, Cananga odorata, Ginkgo Biloba, Bacopa , and Rhodiola rosea , Ashwagandha, Astragalus, Chaga, Cordyceps , Corydalis, Curcumin, Damiana, Eleuthero, Ginger root, Ginseng , Gotu Kola, Lion's Mane, Maca, Passionflower, Saffron, Schisandra, St. John's Wort, Turmeric, Turkey Tail, Valerian root, and Yohimbe;
the one or more nanoparticles further comprises:
a plurality of emulsifying agents selected from the group consisting of an extract of Quillaja, extract of Licorice, polysorbate 20, polysorbate 40, polysorbate 45, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 81 and polysorbate 85, polyglyceryl, gum acacia, Polyglycerol polyricinoleate, sorbitan 85, sorbitan 65, sorbitan 83, sorbitan 80, sorbitan 60, sorbitan 40, Xanthan gum, sorbitol, mannitol, glycerol, sodium alginate, lecithin, chemically modified lecithin, purified components of lecithin, phosphatidylcholine, phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingomyelin, and cardiolipin, hydrogenated soybean phosphatidylcholine, hydrogenated soybean phosphatidylcholine, tocopherol polyethylene glycol succinate, fatty acid mono-and di-glycerides, acetic acid esters of mono-and di-glycerides, lactic acid esters of mono-and di-glycerides, citric acid esters of mono-and di-glycerides, diacetyl tartaric acid ester of mono-and di-glycerides, triglycerol monooleate, hexaglycerol octasterate, polyglycerol esters of oleic acid, decaglycerol mono-and di-oleate, glyceryl caprylate, glyceryl caprate, glyceryl caprate/caprylate, glyceryl monooleate, glycerly monostearate, poloxamers, milk proteins, casein, pea proteins, whey proteins, collagen, sodium stearoyl lactylate, extract of bacopa, withaferin A, withaferin B, withanolide A, withanolide B, withanolide C, withanolide D, withanolide E, withanolide F, withanolide G, withanoside I, withanoside II, withanoside III, withanoside IV, withanoside V, withanoside VI, withanoside VII, bacopaside I, bacopaside II, bacopaside III, bacopaside IV, bacopaside V, bacopaside VI, bacopaside VII, bacopaside VIII, bacopaside IX, bacopaside X, bacopaside XI, bacopaside XII, bacopaside N1, bacopaside N2, bacosaponin A, bacosaponin B, bacosaponin C, bacosaponin D, bacosaponin E, bacosaponin F, bacosaponin G, bacosaponin H, bacoside A3, bacosine, or combinations thereof;
the one or more nanoparticles solubilize the second plurality of active ingredients in the aqueous suspension;
the one or more nanoparticles have a Z-average diameter between 50 to 950 nanometers;
the one or more nanoparticles has a net negative charge that is-15 mV or lower;
the one or more nanoparticles comprise a crosslinked hydrophilic polymer network at an interface of the one or more nanoparticles;
the Z-average diameter of the one or more nanoparticles changes less than 20% when the aqueous suspension is incubated at 40° C. for four weeks; and
the Z-average diameter of the one or more nanoparticles changes less than 20% when the aqueous suspension is incubated at 90° C. for 30 minutes.