Compositions comprising cetylated fatty acids for use in the treatment of gastric mucosa, diabetes and high blood glucose levels
A composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and an antioxidant in reduced percentages by weight, and related methods for treatment of arthritis and of inflammatory joint and musculoskeletal pain. Furthermore a composition is described comprising a mixture of at least one cetylated fatty acid or a mixture of cetylated fatty acids and, optionally, an antioxidant, and related treatment methods for protecting the gastric mucosa and for regulating the blood glucose levels. Additionally, a method is described for preparing the at least one cetylated fatty acid or mixture of cetylated fatty acids and for preparing compositions comprising the cetylated fatty acids and the antioxidant.
1 . A method for protective treatment of a disorder or symptom deriving from and/or related with damaging gastric mucosa, selected from gastric ulcers, gastroesophageal reflux (GERD), and heartburn, the method comprising
administering to a subject in need a composition in an effective amount to obtain gastric mucosal protection of the subject, the composition comprising:
(a) a mixture of at least one cetylated fatty acid, comprising, cetylated myristic acid and cetylated oleic acid, at a myristic:oleic mole ratio of about 2.1:1
(b) at least one antioxidant at a % by weight from 0.001% to 0.3% with respect to the total weight of the composition, and
(c) a vegetable oil selected from olive oil, corn oil, mixtures thereof;
wherein the composition optionally further comprises at least one pharmaceutical or food grade additive and/or excipient.
2 . The method according to claim 1 , wherein said mixture of at least one cetylated fatty acid further comprises lauric acid, palmitic acid, palmitoleic acid, stearic acid, linoleic acid, eicosanoic acid, and mixtures thereof.
3 . The method according to claim 1 , wherein in said mixture of cetylated myristic acid and cetylated oleic acid the mole ratio between the cetylated myristic acid and cetylated oleic acid is from 4:1 to 1:1.
4 . The method according to claim 1 , wherein said at least one antioxidant is selected from tert-butyl-hydroquinone (TBHQ), a mixture comprising tocopherol, lecithin, ascorbyl palmitate and citric acid, and a mixture of tocopherols and a natural extract of rosemary.
5 . The method according to claim 4 , wherein the mixture comprising tocopherol, lecithin, ascorbyl palmitate and citric acid comprises a-tocopherol 10-15% by weight, lecithin >50% by weight, ascorbyl palmitate 8-10% by weight and citric acid <1% by weight.
6 . The method according to claim 1 , wherein said at least one antioxidant is present at a % by weight from 0.001% to 0.5% 0.1% with respect to the total weight of the composition.
7 . The method according to claim 1 , wherein said composition comprises: cetylated myristic acid and cetylated oleic acid and tert-butyl-hydroquinone (TBHQ).
8 . The method according to claim 7 , wherein the mole ratio between the cetylated myristic acid and cetylated oleic acid is from 4:1 to 1:1.
9 . The method according to claim 7 , wherein the mole ratio between the cetylated myristic acid and cetylated oleic acid is from 3:1 to 1.5:1.
10 . The method according to claim 7 , wherein the tert-butyl-hydroquinone (TBHQ) is present at a % by weight comprised from 0.001% to 0.5% with respect to the total weight of the composition.
11 . The method according to claim 7 , wherein the tert-butyl-hydroquinone (TBHQ) is present at a % by weight comprised from 0.005% to 0.1%, with respect to the total weight of the composition.
12 . The method according to claim 1 , wherein said composition is formulated for oral use.
13 . The method according to claim 1 , wherein the administering is performed by
administering said composition as a coadjuvant of one or more additional compositions for protective treatment of the disorder or symptom deriving from and/or related with damaging the gastric mucosa.
14 . The method according to claim 1 , wherein said fatty acid of at least one cetylated fatty acid is selected from myristic acid, oleic acid or cetylated myristic acid and cetylated oleic acid and mixtures thereof.
15 . The method according to claim 1 , wherein in said mixture the mole ratio between the cetylated myristic acid and cetylated oleic acid is from 3:1 to 1.5:1.
16 . The method according to claim 1 , wherein said at least one antioxidant comprises tert-butyl-hydroquinone (TBHQ).
17 . The method according to claim 1 , wherein said at least one antioxidant is present at a % by weight from 0.005% to 0.1%, with respect to the total weight of the composition.
18 . The method according to claim 1 , wherein the vegetable oil further comprises, sunflower oil, or mixtures with high oleic or olein content.