Methods to sensitize cancer cells to immune attack using atractylenolide I

Inventors: Xiongbin Lu (Carmel, IN); Xinna Zhang (Carmel, IN); Kevin Van Der Jeught (Indianapolis, IN)

Assignee: THE TRUSTEES OF INDIANA UNIVERSITY

A61K31/365 A61K40/11 A61K40/32 A61K40/42 A61K45/06 A61P35/00 C12N5/0638

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Quick Facts

Patent No.: US 12691093
App. No.: 18/035,694
Granted: Jul 28, 2026
Kind: B2

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Abstract

The present disclosure relates to compositions and methods to induce or increase immunogenicity in cancerous cells comprising contacting the cancerous cells with atractylenolide I (ATT-I). In some embodiments, the methods include contacting the cancerous cells with ATT-I in combination with a cancer therapeutic agent.

Claims (2)

1 . A method of increasing the presentation of antigen-loaded MHC-I complex on a cancer cell, said method comprising contacting said cancer cell with ATT-I, wherein the cancer cell is a colorectal cancer (CRC) cell.

2 . The method of claim 1 wherein the contact occurs in vivo.