Methods and compositions for treating polyomavirus
Described are compositions and methods for treating polyoma viruses such as JCPyV.
1 . A method of treating polyomavirus infection comprising administration of a therapeutically effective amount of GW-5074.
2 . The method of claim 1 , wherein said polyomavirus comprises JCPyV.
3 . The method of claim 2 , wherein said treating reduces JCPyV infection.
4 . The method of claim 2 , wherein said treating reduces JCPyV progression.
5 . The method of claim 2 , wherein said treating inhibits JCPyV progression.
6 . A method of treating JC polyomavirus (JCPyV)-associated progressive multifocal leukoencephalopathy (PML) comprising administration of a therapeutically effective amount of GW-5074.
7 . The method of claim 6 , wherein said treating reduces JCPyV infection.
8 . The method of claim 6 , wherein said treating results in protection from JCPyV infection.
9 . The method of claim 6 , wherein said treating inhibits JCPyV infection.
10 . The method of claim 6 , wherein said treating reduces a PML symptom.
11 . The method of claim 10 , wherein said symptom comprises clumsiness or loss of coordination, difficulty walking, facial drooping, loss of vision, personality changes, trouble speaking, weak muscles, or seizures.
12 . The method of claim 10 , wherein said patient is an immunosuppressed patient.