Application of riluzole in treatment of oligospermia
An application of riluzole, a non-hormone compound, in a treatment of oligospermia provides a useful help for solving the problem of male sterility, and has potential application prospects in the field of medicine.
1 . A method of treating oligospermia with one of riluzole and a prodrug thereof, comprising:
administering to a subject with oligospermia a drug comprising one of the riluzole and the prodrug thereof.
2 . The method as claimed in claim 1 , the subject is one of male vertebrates and rodents.
3 . The method as claimed in claim 2 , the subject is a mammal.
4 . The method as claimed in claim 3 , the subject is a human.
5 . The method as claimed in claim 1 , wherein the drug is suitable for one of oral, sublingual, nasal, local, pulmonary, percutaneous, and parenteral administrations.
6 . The method as claimed in claim 5 , wherein the drug is suitable for one of the oral administration and intraperitoneal injection administration.
7 . The method as claimed in claim 6 , wherein the drug is in a form of one of tablets, coated tablets, dragee, pills, cachet, gelatin capsules, solutions, emulsions, suspensions, suppositories, ointments, aerosols and injections.
8 . The method as claimed in claim 1 , wherein the oligospermia is caused by at least one selected from the group consisting of testicular injury, cancer therapy comprising chemotherapy with busulfan and radiotherapy, severe systemic diseases, malnutrition, drug abuse, anti-psychotherapy and genetic problems.
9 . The method as claimed in claim 1 , wherein the prodrug is one of a compound represented by the following chemical structural formula:
and a pharmaceutically acceptable salt of the compound;
where R 23 is selected from the group consisting of H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CCH, CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH 2 OCH 2 Ph, CH 2 CH 2 OCH 2 Ph, CH(OH)CH 3 , CH 2 Ph, CH 2 (cyclohexyl), CH 2 (4-OH-Ph), (CH 2 ) 4 NH 2 , (CH 2 ) 3 NHC(NH 2 )NH, CH 2 (3-indole), CH 2 (5-imidazole), CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 CONH 2 and CH 2 CH 2 CONH 2 , and the Ph represents phenyl.
10 . The method as claimed in claim 2 , wherein the prodrug is a compound represented by the following chemical structural formula:
11 . The method as claimed in claim 1 , comprising:
treating the oligospermia by administering one of the riluzole and the prodrug thereof in combination with one of another drug and a therapy.
12 . The method as claimed in claim 11 , wherein one of the another drug and the therapy is one or a combination selected from the group consisting of vitamins, antioxidant, human chorionic gonadotropin (hCG), recombinant human follicle-stimulating hormone (rFSH), gonadotropin-releasing hormone (GnRH), and selective estrogen receptor modulators.
13 . The method as claimed in claim 1 , comprising:
administering to the subject with oligospermia an effective amount of riluzole intraperitoneally at a dose of 3 milligrams per kilogram (mg/kg) of body weight per day.
14 . The method as claimed in claim 1 , comprising:
administering to the subject with oligospermia an effective amount of riluzole orally at a dose of 5 mg/kg of body weight per day.