Compositions for inhibition of herpesviruses
The disclosure herein provides compounds of formulas I-V which are useful in the inhibition of viral diseases in a subject. In some embodiments, the compounds of formulas I-V are useful in the inhibition of herpes viruses.
1 . A method of inhibiting a human herpesvirus in a subject in need thereof, comprising administering to the subject a compound of formula I or a pharmaceutical composition thereof comprising a pharmaceutically acceptable carrier, wherein formula I is:
or a salt, solvate, or stereoisomer thereof,
wherein R 1 is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl optionally substituted with one or more amidinyl, guanidinyl, phosphate, sulfate, tetrazole, 3-hydroxyisoxazole, secondary amides, sulfonamides, sulfonyl ureas, acylamidines, acylguanidines, having 1 to 10 carbon atoms and linked via a C 1 -C 3 alky group.
2 . The method of claim 1 , wherein the compound is formula I and selected from the group consisting of:
3 . The method of claim 1 , wherein the herpesvirus is selected from the group consisting of human herpesvirus 1 (HHV-1), human herpesvirus 2 (HHV-2), human herpesvirus 3 (HHV-3), human herpesvirus 4 (HHV-4), human herpesvirus 5 (HHV-5), human herpesvirus 61 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8).
4 . The method of claim 3 , wherein the herpesvirus is HHV-5, and further wherein the HHV-5 is ganciclovir resistant.
5 . The method of claim 1 , further comprising administering more than one biologically active agent.
6 . The method of claim 1 , further comprising administering ganciclovir or letermovir.