Methods of controlling and improving brain health
The present disclosure relates to a method of inducing a neuroprotective state comprising administering a Bromodomain and Extra-Terminal motif (BET) inhibitor under conditions effective to induce a neuroprotective state. Also disclosed are methods of preventing and/or treating neurodegenerative disease, methods of reducing microglial inflammation, and methods of restoring microglial homeostasis, where the methods include administering a Bromodomain and Extra-Terminal motif (BET) inhibitor.
1 . A method of treating Huntington's disease, the method comprising:
administering IBET858 to a subject in need thereof.
2 . The method of claim 1 , wherein IBET858 is administered in an amount between about 10 mg/kg and about 100 mg/kg.
3 . The method of claim 1 , wherein IBET858 is administered once daily for about 1 week.
4 . The method of claim 1 , wherein said administering is carried out intraperitoneally, orally, parenterally, nasally, subcutaneously, intravenously, intramuscularly, intracerebroventricularly, intraparenchymally, by inhalation, intranasal instillation, by implantation, by intracavitary or intravesical instillation, intraocularly, intraarterially, intralesionally, transdermally, topically, intradermally, intrapleurally, intrathecally, or by application to mucous membranes.