Use of micro- and nano-MgH2 compound particles in inhibition of leishmania infection and treatment of leishmaniasis
A use of micro- and nano-MgH 2 compound particles in the inhibition of Leishmania infection and in the treatment of Leishmaniasis is provided. The micro- and nano-MgH 2 compound particles can be used to prepare a pharmaceutical composition for inhibiting Leishmania or to prepare a pharmaceutical composition for treating a skin or mucosal ulcer or visceral damage caused by Leishmania infection. The present disclosure discovers for the first time that the micro- and nano-MgH 2 compound particles can significantly reduce the number of Leishmania in macrophages and inhibit the proliferation of Leishmania , indicating a very prominent insecticidal inhibition effect. The micro- and nano-MgH 2 compound particles of the present disclosure can quickly and effectively cure a skin ulcer and/or a mucosal ulcer caused by Leishmania and an impaired function of an internal organ (mainly liver and spleen) caused by Leishmania and have high biosafety and huge clinical application values.
1 . A method of inhibiting Leishmania comprising a step of administering a pharmaceutical composition to a subject in need thereof, wherein the pharmaceutical composition comprises micro- and nano-MgH 2 compound particles and a pharmaceutically acceptable carrier and/or adjuvant; and an effective concentration of MgH 2 is 1 mg/100 uL to 15 mg/100 uL, wherein the micro- and nano-MgH 2 compound particles each have the particle diameter of 100 nm to 1,000 nm.
2 . A method of treating a skin or mucosal ulcer caused by a Leishmania infection comprising a step of administering a pharmaceutical composition to a subject in need thereof, wherein the pharmaceutical composition comprises micro- and nano-MgH 2 compound particles and a pharmaceutically acceptable carrier and/or adjuvant and an effective concentration of MgH 2 is 1 mg/100 uL to 15 mg/100 L wherein the micro- and nano-MgH 2 compound particles each have the particle diameter of 100 nm to 1,000 nm.
3 . A method of treating a visceral damage caused by a Leishmania infection comprising a step of administering a pharmaceutical composition to a subject in need thereof, wherein the pharmaceutical composition comprises micro- and nano-MgH 2 compound particles and a pharmaceutically acceptable carrier and/or adjuvant and an effective concentration of MgH 2 is 60 mg/kg to 500 mg/kg wherein the micro- and nano-MgH 2 compound particles each have the particle diameter of 100 nm to 1,000 nm.