Drug transdermal delivery system

1 . A drug transdermal delivery method, comprising:

operations of:

firstly applying a low-frequency sonophoresis to skin, wherein a frequency of the low-frequency sonophoresis is 10-30 kHZ, and a time during which the low-frequency sonophoresis is applied is 2 minutes or less,

then massaging a surface of the skin with sponge spicules for 2 minutes, wherein a dosage amount of the sponge spicules is 1 mg/cm 2 or less, and

then administering a drug to the surface of the skin; or

operations of:

firstly applying the low-frequency sonophoresis on the skin, wherein the frequency of the low-frequency sonophoresis is 10-30 kHZ, and the time during which the low-frequency sonophoresis is applied is 2 minutes or less,

then massaging the surface of the skin using the sponge spicules for 2 minutes, wherein the dosage amount of the sponge spicules is 1 mg/cm 2 or less, and

administering the drug to the surface of the skin at the same time as the surface of the skin is massaged using the sponge spicules.

2 . The method according to claim 1 , comprising:

cleaning the skin before administrating the drug to the surface of the skin.

3 . The method according to claim 1 , comprising:

administering the drug within 72 hours after applying the low-frequency sonophoresis to the skin and then massaging the surface of the skin with the sponge spicules.

4 . The method according to claim 1 , wherein an output power for the low-frequency sonophoresis is 5-7 W/cm 2 .

5 . The method according to claim 1 , wherein the sponge spicules are sponge spicules of Haliclona sp.

6 . The method according to claim 1 , wherein the frequency of the low-frequency sonophoresis is 15-28 kHZ.

7 . The method according to claim 1 , wherein:

the time during which the low-frequency sonophoresis is applied is 2 minutes, and

massaging the surface of the skin with the sponge spicules comprises applying a solution of the sponge spicules with a concentration of 20 mg per mL of the solution.