Ionic nanovesicle suspension and biocide prepared therefrom
View Patent ↗A stable suspension, containing water, petrolatum, and at least one ionic biocide compound, wherein the suspension contains no added emulsifier, and all ionic biocide compounds present are either all cationic or all anionic, an ointment containing the stable suspension, and a method for producing the stable suspension.
1 . A method of making a non-separating, non-coalescing, non-flocculating stable suspension comprising combining petrolatum at a temperature about 37° C. to about 45° C., with a liquid biocide to form nanovesicles of liquid biocide suspended in said petrolatum, said liquid biocide comprising a biocide and water mixture, said biocide comprising substantially all cationic molecules or all anionic molecules.
2 . A method as in claim 1 , wherein said petrolatum is at a temperature just above its melting point of approximately 37° C.
3 . A method as in claim 1 , wherein said petrolatum is at a temperature within the range of 37° C. to 40° C.
4 . A method as in claim 1 , wherein said petrolatum is at about 40° C.
5 . The method of claim 1 , wherein all ionic biocide compounds present are all cationic biocides.
6 . The method of claim 1 , wherein all ionic biocide compounds present are all anionic biocides.
7 . The method of claim 1 , wherein the at least one ionic biocide compound is selected from the group consisting of polyhexanide (PHMB), polyaminopropyl biguanide (PAPB), benzalkonium chloride, stearalkonium chloride, and sodium hypochlorite utilizing the salt forms where necessary to attain an ionic state.
8 . The method of claim 7 , wherein the at least one ionic biocide compound is a combination of PHMB and benzaikonium chloride, utilizing the salt forms where necessary to attain an ionic state.
9 . The method of claim 1 , wherein the suspension further comprises at least one nonionic biocide compound.
10 . The method of claim 1 , wherein the suspension further comprises at least one additional medicament.
11 . The method of claim 10 , wherein the at least one additional medicament is a steroid.
12 . The method of claim 11 , wherein the steroid is cortisone.
13 . A non-separating, non-coalescing, non-flocculating stable suspension consisting of water, petrolatum and at least one cationic biocide; and optionally mineral oil, where the at least one cationic biocide is contained within nanovesicles having a diameter of 100 microns or less.