Microfluidic reactor for controlling chemical reaction and chemical reaction control method using the same
The present invention relates to a microfluidic reactor for controlling a chemical reaction and a chemical reaction control method using the same, and more specifically provides a microfluidic reactor capable of controlling a chemical reaction on an expanded scale and a microfluidic reaction device including the same. In addition, the present invention provides an ultrafast synthesis method for controlling unstable intermediates using the microfluidic reactor and microfluidic reaction device.
1 . A microfluidic reaction device which is capable of controlling a chemical reaction, comprising:
a plurality of microfluidic reactors wherein each microfluidic reactor of the plurality of microfluidic reactors is capable of controlling the chemical reaction between a plurality of fluids, wherein each microfluidic reactor of the plurality of microfluidic reactors comprises a housing formed of a metal material and having a predetermined volume, a unit flow path module formed inside the housing and comprising a plurality of unit flow paths, each unit flow path having N inlets, where N is an integer of 2 or more, and a single outlet such that N fluids are respectively introduced and mixed and then discharged, a branch flow path module formed inside the housing and comprising N branch flow paths which are all connected to corresponding ones of the N inlets provided in each unit flow path of the plurality of unit flow paths to uniformly branch a fluid introduced into the housing into the plurality of unit flow paths, and a collection flow path formed inside the housing, connected to individual outlets provided in each unit flow path of the plurality of unit flow paths, and collecting a mixed fluid moved from individual outlets provided in each unit flow path of the plurality of unit flow paths and discharging the mixed fluid outside the housing;
N external distributors external to the housing and corresponding in number to the N branch flow paths, which are all connected to inlet ends of the N branch flow paths provided in each microfluidic reactor of the plurality of microfluidic reactors so as to uniformly branch with respect to the plurality of microfluidic reactors after receiving a fluid from the outside; and
an external collector external to the housing and connected to all of outlet ends of the collection flow paths, each collection flow path being provided being provided in a respective one of the plurality of microfluidic reactors so as to collect the mixed fluid discharged from the plurality of microfluidic reactors,
wherein the unit flow path module, the branch flow path module and the collection flow path are monolithically and integrally formed inside the housing in a process of stacking the housing through a 3D printing process.
2 . The microfluidic reaction device of claim 1 , wherein the unit flow path module comprises a first unit flow path, a second unit flow path, a third unit flow path and a fourth unit flow path, and
wherein each N branch flow path of the N branch flow paths constituting the branch flow path module is formed in a four-pronged branching structure and the collection flow path is formed in a four-pronged branching structure.
3 . The microfluidic reaction device of claim 1 , wherein the housing is formed in a hexahedral shape including an upper surface, a lower surface and four side surfaces,
wherein the plurality of unit flow paths is arranged in parallel along a height direction of the housing,
wherein the branch flow path module comprises three branch flow paths, wherein each of the three branch flow paths is disposed adjacent to a respective one of three different side surfaces among the four side surfaces, and
wherein the collection flow path is disposed adjacent to one remaining side surface of the four side surfaces excluding the three side surfaces.
4 . The microfluidic reaction device of claim 1 , wherein the plurality of unit flow paths are connected in parallel so as to maintain a same flow rate.
5 . The microfluidic reaction device of claim 1 , wherein the 3D printing process is performed by selective laser melting.
6 . The microfluidic reaction device of claim 1 , wherein the unit flow path comprises a first inlet, a second inlet, and a third inlet, and
wherein two types of fluids introduced from the first inlet and the second inlet are mixed to generate a first mixed fluid, and then further mixed with a fluid introduced from the third inlet.
7 . The microfluidic reaction device of claim 6 , wherein each unit flow path of the plurality of unit flow paths is formed to have a circular vertical cross section as a whole,
wherein the circular vertical cross section has a diameter of about 500 μm, and
wherein after the first mixed fluid is mixed, a distance from a first mixing point where the first mixed fluid is generated to a second mixing point where the first mixed fluid is mixed with the fluid introduced from the third inlet is about 10 mm, and the moving time of the first mixed fluid from the first mixing point to the second mixing point is within 16 ms.
8 . The microfluidic reaction device of claim 1 , further comprising a metal frame formed of a metal material and formed to surround an outer surface of the housing,
wherein the metal frame is provided with N+1 coupling holes such that N+1 tube fixing members are screwed to be in close contact with the outer surface of the housing.
9 . The microfluidic reaction device of claim 8 , comprising 4 microfluidic reactors so as to have 16 unit flow paths in total.