IP Library › Granted Patent US 12692234
Granted Patent B2
US 12692234 · App. 19/253,364 · Granted Jul 28, 2026

Rock inhibitors and uses thereof

Inventors: Casey Casimir Kopczynski (Chapel Hill, NC); Jill Marie Sturdivant (Chapel Hill, NC); Michael Scott McClure (Cary, NC); Anjali Biren Joshi (Cary, NC)
Assignee: Alcon Inc.
C07D217/02A61K9/0048A61K31/472A61K31/5575A61K47/02A61K47/186A61K47/26A61P27/06A61P27/14
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Quick Facts
Patent No.
US 12692234
App. No.
19/253,364
Granted
Jul 28, 2026
Kind
B2
Abstract

Provided herein are compounds comprising a formula of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl adamantane carboxylate (e.g., compounds of formula (I) or formula (II)) or a pharmaceutically acceptable salt thereof. The compounds are useful for reducing intraocular pressure and for treating glaucoma or ocular hypertension.

Claims (4)

1 . A compound, having the formula:

or a pharmaceutically acceptable salt thereof.

2 . The compound of claim 1 , which is a monomesylate salt of 4-((S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl adamantane-1-carboxylate.

3 . The compound of claim 1 , which is a dimesylate salt of 4-((S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl adamantane-1-carboxylate.