Method for preparing fluralaner
Provided is a method for preparing fluralaner. The method includes: mixing 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid, a catalyst, an alcohol and an organic solvent to obtain a mixture, and subjecting the mixture to esterification to obtain an esterification solution containing 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoate; and mixing the esterification solution with 2-amino-N-(2,2,2-trifluoroethyl)acetamide to obtain a mixed solution and subjecting the mixed solution to ester decomposition-amidation to obtain the fluralaner.
1 . A method for preparing fluralaner, comprising the following steps:
mixing 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid, a catalyst, an alcohol and an organic solvent to obtain a mixture, and subjecting the mixture to esterification to obtain an esterification solution containing 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoate; and
mixing the esterification solution and 2-amino-N-(2,2,2-trifluoroethyl)acetamide to obtain a mixed solution, and subjecting the mixed solution to ester decomposition-amidation to obtain the fluralaner.
2 . The method according to claim 1 , wherein the catalyst is one or more selected from the group consisting of p-toluenesulfonic acid, sulfuric acid, phosphoric acid, sulfonic acid resin, phosphotungstic acid, silicotungstic acid, and an aluminosilicate molecular sieve.
3 . The method according to claim 1 , wherein a weight ratio of the catalyst to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (0.001-0.2):1.
4 . The method according to claim 1 , wherein the alcohol is one or more selected from the group consisting of methanol, ethanol, isopropanol, and n-propanol.
5 . The method according to claim 1 , wherein a molar ratio of the alcohol to the 4-(5-(3,5-dichlorophenyl)-5-(1-10):1.
6 . The method according to claim 1 , wherein the organic solvent is one or more selected from the group consisting of toluene, xylene, ethylbenzene, and cyclohexane.
7 . The method according to claim 1 , wherein a weight ratio of the organic solvent to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (2-8):1.
8 . The method according to claim 1 , wherein the esterification is conducted at a temperature of 70° C. to 130° C. for 2 h to 10 h.
9 . The method according to claim 1 , wherein a molar ratio of the 2-amino-N-(2,2,2-trifluoroethyl)acetamide to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (1-3):1.
10 . The method according to claim 1 , wherein the ester decomposition-amidation is conducted at a temperature of 90° C. to 150° C. for 3 h to 12 h.
11 . The method according to claim 2 , wherein a weight ratio of the catalyst to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (0.001-0.2):1.
12 . The method according to claim 4 , wherein a molar ratio of the alcohol to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (1-10):1.
13 . The method according to claim 6 , wherein a weight ratio of the organic solvent to the 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl)-2-methyl-benzoic acid is in a range of (2-8):1.
14 . The method according to claim 9 , wherein the ester decomposition-amidation is conducted at a temperature of 90° C. to 150° C. for 3 h to 12 h.