Griseofulvin 4 position etherified derivatives and their application

1 . Griseofulvin 4 position etherified derivatives, wherein chemical structures of the griseofulvin 4 position etherified derivatives are shown in a formula I below:

2 . A preparation method of the griseofulvin 4 position etherified derivatives as claimed in claim 1 , comprising:

with organic solvent and base, intermediate II reacted with different bromo compounds, griseofulvin 4 position etherified derivatives are obtained, wherein the different bromo compounds are propargyl bromide, cyclopropylmethyl bromide, and bromocyclopentane;

wherein a chemical structure of the intermediate II is expressed as follows:

3 . The preparation method as claimed in claim 2 , wherein after the reacting is finished, a reaction mixture is obtained, and the preparation method specifically comprises: concentrating the reaction mixture and then purifying the reaction mixture after the concentrating by a column chromatography method, to thereby obtain the griseofulvin 4 position etherified derivatives.

4 . The preparation method as claimed in claim 2 , wherein the organic solvent is but not limited to acetone or tetrahydrofuran (THF) or their mixture.

5 . The preparation method as claimed in claim 2 , wherein the base is but not limited to K 2 CO 3 or Na 2 CO 3 or Cs 2 CO 3 .

6 . A method for controlling phytopathogenic fungi, comprising: applying an effective concentration of the Griseofulvin 4 position etherified derivatives as claimed in claim 1 to a plant infected by the phytopathogenic fungi.

7 . The application as claimed in claim 6 , wherein the phytopathogenic fungi includes one or at least two selected from the group consisting of Cytospora sp., Alternaria solani Sorauer, Alternaria alternate, Botrytis sp., Botrytis cinerea Pers., Colletotrichum gloeosporioides , and Botryosphaeria dothidea.

8 . The method as claimed in claim 6 , wherein the effective concentration is 100 micrograms per milliliter (ug/mL).