Substituted ureas as orexin receptor agonists

1 . A compound of the following formula:

or a pharmaceutically acceptable salt or stereoisomer thereof,

wherein:

R 1 is C 1-6 alkyl, C 2-4 alkenyl, or C 3-6 cycloalkyl;

wherein the C 1-6 alkyl or C 2-4 alkenyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, C(O)N(C 1-6 alkyl) 2 , C(O)OH, C(O)OC 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , OH, OC 1-6 alkyl, OC(O)C 1-6 alkyl, OC(O)N(C 1-6 alkyl) 2 , OC 3-6 cycloalkyl, ═O, S(O) 2 C 1-6 alkyl, S(O) 2 N(C 1-6 alkyl) 2 , S(O) 2 C 3-5 cycloalkyl, C 3-6 cycloalkyl, azetidinyl, oxetanyl, tetrahydrofyranyl, oxo-oxazolidinyl, piperidinyl, tetrahydropyranyl, morpholinyl, oxomorpholinyl, phenyl, imidazolyl, triazolyl, and oxadiazolyl;

wherein the C 3-6 cycloalkyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C(O)N(C 1-6 alkyl) 2 , C(O)OH, C(O)OC 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , OH, OC 1-6 alkyl, OC(O)C 1-6 alkyl, OC(O)N(C 1-6 alkyl) 2 , OC 3-6 cycloalkyl, ═O, S(O) 2 C 1-6 alkyl, S(O) 2 N(C 1-6 alkyl) 2 , S(O) 2 C 3-5 cycloalkyl, C 3-6 cycloalkyl, azetidinyl, oxetanyl, tetrahydrofyranyl, oxo-oxazolidinyl, piperidinyl, tetrahydropyranyl, morpholinyl, oxomorpholinyl, phenyl, imidazolyl, triazolyl, and oxadiazolyl;

wherein each C 1-6 alkyl substituent is optionally and independently substituted with 1, 2, 3, 4, 5, or 6 F substituents;

wherein each C 3-6 cycloalkyl substituent is optionally and independently substituted with 1, 2, 3, 4, 5, or 6 F, 1 C 1-6 alkyl substituent, or 1 CF 3 substituent;

wherein each azetidinyl substituent is optionally and independently substituted with 1 C 1-6 alkyl substituent; and

wherein each tetrahydrofuranyl, piperidinyl, tetrahydropyranyl, and phenyl substituent is optionally and independently substituted with 1 F, 1 C 1-6 alkyl substituent, or 1 CF 3 substituent;

R 5 is CH 3 , CH 2 CH 3 , CH 2 CF 3 , or cyclopropyl;

R 6a is H, C 1-6 alkyl or C 3-6 cycloalkyl;

wherein the C 1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected halogen substituents; and

wherein the C 3-6 cycloalkyl is optionally substituted with 1 halogen substituent or 1 C 1-6 alkyl substituent;

R 6b is H, C 1-6 alkyl or C 3-6 cycloalkyl;

wherein the C 1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected halogen substituents; and

wherein the C 3-6 cycloalkyl is optionally substituted with 1 halogen substituent or 1 C 1-6 alkyl substituent; or

R 6a and R 6b , taken together with the carbon atom to which they are attached, form a C 3-6 cycloalkylidene;

Y is phenylene, pyridinylene, pyridazinylene, pyrimidinylene, pyrazinylene, pyridofuranylene, or imidazopyridinylene, wherein the phenylene, pyridinylene, pyridazinylene, pyrimidinylene, pyrazinylene, pyridofuranylene, or imidazopyridinylene is optionally substituted with one or more independently selected R 4 substituents;

each R 4 is independently halogen, C 1-6 alkyl, C 2-6 alkenyl, OH, OC 1-6 alkyl, or SC 1-4 alkyl, wherein each C 1-6 alkyl, C 2-6 alkenyl, or OC 1-6 alkyl is optionally and independently substituted with 1, 2, 3, 4, 5, or 6 F substituents;

A is C;

D is CH, CH═CH, N, or N═CH;

E is CH or N;

G is CH, CCl, CCH 3 , or N;

J is CH, CCl, CCH 3 , CCH 2 OCH 3 , COCH 3 , or N;

K is CR 7 or N;

R 7 is H, halogen, C 1-6 alkyl, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , OC 1-6 alkyl, or SC 1-4 alkyl;

wherein the C 1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected halogen substituents or 1 OC 1-6 alkyl substituent; and

wherein the OC 1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected halogen substituents; and

R 8 is H, halogen, CN, C 1-6 alkyl, NH 2 , or OH, wherein the C 1-6 alkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected halogen substituents.

2 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 1 is C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of F and cyclopropyl.

3 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:

R 6a is CH 3 or CF 3 ; and

R 6b is H.

4 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein each R 4 is independently C 1-6 alkyl, OH, or OC 1-6 alkyl.

5 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein

is:

6 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein

is

7 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 7 is H, CH 3 , or OCH 3 .

8 . The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 8 is H or CH 3 .

9 . A pharmaceutical composition comprising an inert carrier and a compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof.

10 . A method for treating hypersomnia in a subject, wherein the method comprises administering to the subject in need thereof a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof.

11 . The method of claim 10 wherein the subject is a mammal.

12 . A method for treating narcolepsy in a subject, wherein the method comprises administering to the subject in need thereof a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof.

13 . The method of claim 12 wherein the subject is a mammal.

14 . A compound selected from the group consisting of:

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(3-(imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)urea;

1-ethyl-3-((R)-1-(3-fluorophenyl)ethyl)-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-((1R,3S)-3-(trifluoromethyl)cyclopentyl)urea;

3-((R)-1-(4,4-difluorocyclohexyl)ethyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

(R)-1-ethyl-1-(1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(2,2,2-trifluoroethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(((S)-5-oxomorpholin-3-yl)methyl)urea;

3-(2-(dimethylamino)-3,3,3-trifluoropropyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)urea;

(R)-1-ethyl-1-(4-methoxy-3-(8-methoxyimidazo[1,2-a]pyridin-6-yl)benzyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

3-(1-(3,3-difluorocyclohexyl)ethyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

3-(cyano(cyclopentyl)methyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

ethyl 3-(3-ethyl-3-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)ureido)-4,4,4-trifluorobutanoate

3-(cyano(3-(trifluoromethyl)phenyl)methyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

3-(3-(dimethylamino)-1,1,1-trifluoropropan-2-yl)-1-ethyl-1-((R)-1-(3-(7-methoxypyrazolo[1,5-a]pyridin-5-yl)phenyl)ethyl)urea;

3-(3-cyano-1,1,1-trifluoropropan-2-yl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(2,2,2-trifluoro-1-(1-methylazetidin-3-yl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(1,1,1-trifluoro-3-(2H-1,2,3-triazol-2-yl)propan-2-yl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(1,1,1-trifluoro-3-(1H-1,2,3-triazol-1-yl)propan-2-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea;

1-ethyl-3-(1,1,1,5,5,5-hexafluoro-4-methylpentan-2-yl)-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluoro-5-methylhexan-3-yl)urea;

3-(1-(4,4-difluoro-6,6-dimethyltetrahydro-2H-pyran-2-yl)-2,2,2-trifluoroethyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1-cyclobutyl-2,2,2-trifluoroethyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1-cyclopropyl-2,2,2-trifluoroethyl)-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1-cyclopropyl-2,2-difluoroethyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,1-trifluorobutan-2-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(2-(trifluoromethyl)cyclobutyl)urea;

3-(1,1-difluorobutan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(3,3,3-trifluoro-2-methylpropyl)urea;

(S)-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1-(trifluoromethyl)cyclobutyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(7-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)furo[3,2-b]pyridin-5-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(8-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)imidazo[1,2-a]pyridin-6-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-(7-methoxypyrazolo[1,5-a]pyridin-5-yl)-6-(methylthio)pyridin-3-yl)ethyl)urea;

1-(cyclopropyl(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)methyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-(2,2-difluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

3-((S)-3-cyclopropoxy-1,1,1-trifluoropropan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-cyclopropyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-(2,2-difluoroethyl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

N-ethyl-N′—[(2S)-1,1,1,5,5,5-hexafluoropentan-2-yl]-N-{2,2,2-trifluoro-1-[3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl]ethyl}urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(3-(imidazo[1,2-a]pyridin-6-yl)-4-methoxyphenyl)ethyl)urea;

3-((R)-1-(cyanomethyl)piperidin-3-yl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

(R)-3-(2-cyanopropan-2-yl)-1-ethyl-1-(1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-3-(1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((1R,2R)-2-methyl-2-(trifluoromethyl)cyclopropyl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,1-trifluoro-3,3-dimethylbutan-2-yl)urea;

(S)-1-ethyl-3-isopropyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

(S)-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(3-(2,2,2-trifluoroethyl)cyclobutyl)urea;

1-ethyl-3-((1R,2R)-1-methyl-2-(trifluoromethyl)cyclopropyl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

(S)-3-cyclopropyl-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1-(4,4-difluorotetrahydro-2H-pyran-2-yl)-2,2,2-trifluoroethyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1,1,1-trifluoro-4-oxopentan-2-yl)urea;

3-((S)-4-cyano-1,1,1-trifluorobutan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,1-trifluoro-4-(methylsulfonyl)butan-2-yl)urea;

3-(1-cyanobutyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

(S)-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(3-(trifluoromethyl)cyclobutyl)urea;

1-ethyl-3-((1S,2R)-2-methyl-2-(trifluoromethyl)cyclopropyl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(3,3-difluorobutan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1,1-difluoropropan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(2,2-difluorocyclopropyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1,1,1-trifluoro-3-(2-oxooxazolidin-3-yl)propan-2-yl)urea;

1-ethyl-3-((2S)-1,1,1,5,5,5-hexafluoro-4-methoxypentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(4,4,4-trifluoro-1-(oxetan-2-yl)butyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1,1,1-trifluoro-3-(tetrahydrofuran-2-yl)propan-2-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(2,2,2-trifluoro-1-(tetrahydro-2H-pyran-3-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(2,2,2-trifluoro-1-(tetrahydro-2H-pyran-4-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(5,5,5-trifluoro-1-methoxypentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-methoxy-4-(7-methoxypyrazolo[1,5-c]pyrimidin-5-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(1,1,1,4,4-pentafluorobutan-2-yl)urea;

3-(1-(4,4-difluoro-1-methylpiperidin-2-yl)-2,2,2-trifluoroethyl)-1-ethyl-1-((R)-1-(3-(7-methoxypyrazolo[1,5-a]pyridin-5-yl)phenyl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(1,1,1-trifluoro-5-oxohexan-2-yl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(2,2,6,6,6-pentafluorohexan-3-yl)urea;

3-((1R)-1-(4,4-difluorotetrahydro-2H-pyran-2-yl)propyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

3-(3-(1-ethoxycyclopropyl)-1,1,1-trifluoropropan-2-yl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-1-methyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-1-propyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-isopropyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-(2,2-difluoroethyl)-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-(2,2,2-trifluoro-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(1-(2-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyrimidin-4-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(1-(6-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridazin-4-yl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluorohex-1-yn-3-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(2,2,2-trifluoro-1-(3-fluorophenyl)ethyl)urea;

1-ethyl-3-(1-methyl-6-(trifluoromethyl)piperidin-3-yl)-1-((S)-2,2,2-trifluoro-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

(R)-1,3-diethyl-1-(1-(3-(8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)urea;

3-((1S)-1-(3,3-difluorocyclohexyl)-2,2,2-trifluoroethyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5-tetrafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5-pentafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,6,6-hexafluorohex-5-en-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-((S)-3-cyclopropyl-1,1,1-trifluoropropan-2-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(4-cyclopropyl-1,1,1-trifluorobutan-2-yl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-(1,1,1-trifluorohept-6-yn-2-yl)urea;

1-ethyl-3-((S)-1,1,5,5,5-pentafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,5,5-tetrafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,5-trifluoropentan-2-yl)urea;

1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((S)-1,1,1-trifluoropent-4-en-2-yl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-((S)-1,1,1-trifluoro-4-methylpent-3-en-2-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1,1,1-trifluorobut-3-yn-2-yl)urea;

3-((R)-6,6-difluorohexan-3-yl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((R)-1,1,1-trifluoropentan-3-yl)urea;

3-(1-cyclopropyl-3,3,3-trifluoropropyl)-1-ethyl-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-(1-cyclopropyl-4-fluorobutyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-((E)-6,6,6-trifluorohex-4-en-3-yl)urea;

1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)-3-(1-(2-(trifluoromethyl)cyclopropyl)propyl)urea;

3-((S)-1-cyclopropyl-4,4-difluorobutyl)-1-ethyl-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-((R)-1-(3-(8-(difluoromethoxy)imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(7-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(8-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(8-(methoxymethyl)imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(7-chloropyrazolo[1,5-a]pyridin-5-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(7-(methoxymethyl)imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(8-(methylthio)imidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(8-ethoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(4-methoxy-3-(8-methylimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(8-aminoimidazo[1,2-a]pyridin-6-yl)-4-methoxyphenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(4-methoxy-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(imidazo[1,2-a]pyrimidin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(7-methylimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(3-(3-chloro-8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-((R)-1-(3-(2-chloro-8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(3-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)ethyl)urea;

1-((R)-1-(3-(3-aminoimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-((R)-1-(3-(3,5-dichloro-8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-((R)-1-(3-(7-chloroimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyridin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((S)-1-(4-(8-ethylimidazo[1,2-a]pyrazin-6-yl)-5-methoxypyridin-2-yl)-2,2,2-trifluoroethyl)-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-5-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-methoxy-4-(4-methoxybenzo[d]oxazol-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-1-((R)-1-(4-(7-ethylpyrazolo[1,5-a]pyridin-5-yl)-5-methoxypyridin-2-yl)ethyl)-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(4-methoxy-1-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(7-methoxypyrazolo[1,5-a]pyrimidin-5-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(4-(8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-methoxypyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(4-methoxyimidazo[2,1-f][1,2,4]triazin-2-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

(R)-1-ethyl-1-(5-(imidazo[1,2-a]pyridin-6-yl)-2,4-dimethoxybenzyl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridazin-3-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-6-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyrazin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)-6-methylpyridin-2-yl)ethyl)urea;

1-(1-(4-(2-cyano-8-methoxyimidazo[1,2-a]pyridin-6-yl)-5-methoxypyridin-2-yl)-2,2,2-trifluoroethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(4-methoxythiazolo[4,5-c]pyridin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxy-2-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyquinolin-6-yl)pyridin-2-yl)ethyl)urea;

1-(1-(4-(3-cyano-8-methoxyimidazo[1,2-a]pyrazin-6-yl)-5-methoxypyridin-2-yl)-2,2,2-trifluoroethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-4-(8-methoxyquinoxalin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(5-methoxy-4-(7-methoxy-1H-benzo[d]imidazol-5-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(6-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(2-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)-6-methylpyridin-3-yl)ethyl)urea;

1-ethyl-1-((R)-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)-3-((S)-1,1,1,5,5-pentafluorohexan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-methoxy-6-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((S)-2,2,2-trifluoro-1-(4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)-5-methylpyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(2,2,2-trifluoro-1-(5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)urea;

1-ethyl-1-((R)-1-(7-(imidazo[1,2-a]pyridin-6-yl)-2,3-dihydrobenzofuran-5-yl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(2-fluoro-5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxyphenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-((R)-1-(4-bromo-3-(imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-methoxy-4-(7-methoxypyrazolo[1,5-a]pyridin-5-yl)pyridin-2-yl)ethyl)urea;

1-((R)-1-(3-(6-amino-5-methoxypyridin-3-yl)phenyl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

3-((S)-1-cyclopropyl-4,4,4-trifluorobutyl)-1-ethyl-1-((R)-1-(6-methoxy-5-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-methoxy-4-(8-methoxy-3-methylimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(1-(2-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-4-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-(1-(6-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyrimidin-4-yl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)ethyl)urea;

1-((R)-1-(4-chloro-3-(8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)-1-ethyl-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-(1-(5-chloro-4-(8-fluoroimidazo[1,2-a]pyridin-6-yl)pyridin-2-yl)ethyl)-1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-1-(1-(4-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-5-methoxypyridin-2-yl)ethyl)-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

3-(cyano(3,3-difluorocyclohexyl)methyl)-1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)urea;

N′-{3-[(dimethylsulfamoyl)amino]-1,1,1-trifluoropropan-2-yl}-N-ethyl-N-{(1R)-1-[3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl]ethyl}urea;

(R)-1-ethyl-1-(2-(3-(imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-yl)-3-(6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(imidazo[1,2-a]pyridin-6-yl)-4-vinylphenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-1-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)-3-((S)-1,1,1-trifluoro-4-methylpent-3-en-2-yl)urea;

2-(3-ethyl-3-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)ureido)-3,3,3-trifluoropropyl acetate;

2-(3-ethyl-3-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)ureido)-3,3,3-trifluoropropyl acetate;

2-(3-ethyl-3-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)ureido)-3,3,3-trifluoropropyl dimethylcarbamate;

3-(3-ethyl-3-((R)-1-(3-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)phenyl)ethyl)ureido)-4,4,4-trifluoro-N,N-dimethylbutanamide;

1-ethyl-1-((R)-1-(3-(7-methoxyindolin-5-yl)phenyl)ethyl)-3-((R)-6,6,6-trifluorohexan-3-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(3-(2-hydroxy-8-methoxyimidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(3-(8-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)phenyl)ethyl)urea;

(S)-1-(2,2-difluoro-1-(5-methoxy-4-(8-methoxyimidazo[1,2-a]pyrazin-6-yl)pyridin-2-yl)vinyl)-1-ethyl-3-(1,1,1,5,5,5-hexafluoropentan-2-yl)urea;

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(5-(8-methoxy-imidazo[1,2-a]pyrazin-6-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)ethyl)urea; and

1-ethyl-3-((S)-1,1,1,5,5,5-hexafluoropentan-2-yl)-1-((R)-1-(6-hydroxy-5-(7-methoxypyrazolo[1,5-a]pyridin-5-yl)pyridin-3-yl)ethyl)urea; or a pharmaceutically accept or stereoisomer thereof.