Pyrimidine or pyridine derivative, preparation method therefor, and application thereof in pharmacy
A pyrimidine or pyridine derivative having a structure represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as an EGFR inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing cancer, tumors, or metastatic diseases associated at least in part with EGFR exon 20 insertions, deletions, or other mutations, especially a use thereof in the preparation of a drug for treating and/or preventing hyperproliferative diseases and the induction of cell death disorders.
1 . A compound of formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof:
wherein,
X is CH or N;
Y 1 and Y 2 are each independently CH or N;
Z is CR 11 or N;
R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 , or R 1 and adjacent R 10 , together with the moiety to which R 1 and adjacent R 10 are directly attached, form a C 3-12 cycloalkyl or 3-12 membered heterocyclyl, each of the above R 1 or R 1 and adjacent R 10 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, ═O, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ;
R 2a and R 2b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl, or R 2a and R 2b , together with the carbon atom to which R 2a and R 2b are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 2a and R 2b groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, ═O, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ;
R 3a and R 3b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl;
R 4 is selected from the group consisting of hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl, each of the above R 4 groups optionally independently further substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, ═O, cyano, C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 ;
R 5 is selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl;
R 6 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ;
R 7 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ;
R 8 and R 9 are each independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 3-12 membered heterocyclyl, each of the above R 8 and R 9 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 ;
or, R 5 and one of R 6 , R 7 , or R 8 , together with the moiety to which R 5 and one of R 6 , R 7 , or R 9 are directly attached, form a 4-6 membered heterocyclyl, the other two of R 6 , R 7 , and R 9 are as previously defined, the 4-6 membered heteorcyclyl is optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, ═O, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ,
or R 7 and R 8 , together with the moiety to which R 7 and R 8 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl is optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, ═O, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ,
or
is
each R 10 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 , or when m=2, two R 10 , together with the moiety to which the two R 10 are directly attached, form a C 3-12 cycloalkyl or 3-12 membered heterocyclyl;
R 11 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, —C 0-8 alkyl-SF 5 , —C 0-8 alkyl-S(O) r R 12 , —C 0-8 alkyl-O—R 13 , —C 0-8 alkyl-C(O)OR 13 , —C 0-8 alkyl-C(O)R 14 , —C 0-8 alkyl-O—C(O)R 14 , —C 0-8 alkyl-NR 15 R 16 , —C 0-8 alkyl-C(═NR 15 )R 14 , —C 0-8 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-8 alkyl-C(O)NR 15 R 16 , and —C 0-8 alkyl-N(R 15 )—C(O)R 14 ;
each R 12 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, and —C 0-8 alkyl-NR 15 R 16 , each of the above R 12 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, oxo, C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 ;
each R 13 is independently selected from the group consisting of hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl, each of the above R 13 groups independently optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, oxo, cyano, C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 ;
each R 14 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 , each of the above R 14 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, cyano, C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and —C 0-8 alkyl-NR 15 R 16 ;
each of R 15 and R 16 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkoxy, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, sulfinyl, sulfonyl, methylsulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, dimethylaminosulfonyl, amino, monoC 1-10 alkylamino, diC 1-10 alkylamino, and C 1-10 alkanoyl, each of the above R 15 and R 16 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, amino, monoC 1-10 dialkylamino, diC 1-10 alkylamino, and C 1-10 alkanoyl,
or, R 15 and R 16 , together with the nitrogen atom to which R 15 and R 16 are directly attached, form a 5-10 membered heterocyclyl or 5-10 membered heteroaryl, each of the above R 15 and R 16 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, C 1-10 deuterioalkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkyloxy, 3-12 membered heterocyclyl, 3-12 membered heterocyclyloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, amino, monoC 1-10 alkylamino, diC 1-10 alkylamino, and C 1-10 alkanoyl;
m is 0, 1, or 2;
n is 0, 1, or 2; and
each r is independently 0, 1, or 2.
2 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 1 , wherein Z is CR 11 or N;
R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 , or R 1 and adjacent R 10 , together with the moiety to which R 1 and adjacent R 10 are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 1 or R 1 and adjacent R 10 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ;
R 2a and R 2b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, and 5-8 membered heteroaryl, or R 2a and R 2b , together with the carbon atom to which R 2a and R 2b are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 2a and R 2b groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ;
R 3a and R 3b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, and 5-8 membered heteroaryl;
R 4 is selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, and 5-8 membered heteroaryl, each of the above R 4 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, ═O, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 ;
R 5 is selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl;
R 6 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ;
R 7 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ;
R 8 and R 9 are each independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 3-6 membered heterocyclyl, each of the above R 8 and R 9 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 ;
or, R 5 and one of R 6 , R 7 , or R 9 , together with the moiety to which R 5 and one of R 6 , R 7 , or R 9 are directly attached, form a 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ,
or R 7 and R 8 , together with the moiety to which R 7 and R 8 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 ,
or
is
each R 10 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 , or when m=2, two R 10 , together with the moiety to which the two R 10 are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl; and
R 11 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —C 0-4 alkyl-SF 5 , —C 0-4 alkyl-S(O) r R 12 , —C 0-4 alkyl-O—R 13 , —C 0-4 alkyl-C(O)OR 13 , —C 0-4 alkyl-C(O)R 14 , —C 0-4 alkyl-O—C(O)R 14 , —C 0-4 alkyl-NR 15 R 16 , —C 0-4 alkyl-C(═NR 15 )R 14 , —C 0-4 alkyl-N(R 15 )—C(═NR 16 )R 14 , —C 0-4 alkyl-C(O)NR 15 R 16 , and —C 0-4 alkyl-N(R 15 )—C(O)R 14 .
3 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 1 , wherein each R 12 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and —C 0-4 alkyl-NR 15 R 16 , each of the above R 12 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, oxo, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 ;
each R 14 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 , each of the above R 14 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 , each of the above R 14 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 ; and
each of R 15 and R 16 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, sulfinyl, sulfonyl, methylsulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, dimethylaminosulfonyl, amino, monoC 1-4 alkylamino, diC 1-4 alkylamino, and C 1-4 alkanoyl, each of the above R 15 and R 16 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, monoC 1-4 alkylamino, diC 1-4 alkylamino, and C 1-4 alkanoyl,
or, R 15 and R 16 , together with the nitrogen atom to which R 15 and R 16 are directly attached, form a 5-8 membered heterocyclyl or 5-8 membered heteroaryl, each of the above R 15 and R 16 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, monoC 1-4 alkylamino, diC 1-4 alkylamino, and C 1-4 alkanoyl.
4 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 1 , wherein the compound of formula (I) is a compound of formula (II):
wherein,
Y is CH or N;
Z is CH or N;
R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 , or R 1 and R 10 , together with the moiety to which R 1 and R 10 are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 1 or R 1 and adjacent R 10 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ;
R 2a and R 2b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl, or R 2a and R 2b , together with the carbon atom to which R 2a and R 2b are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 2a and R 2b groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ;
R 3a and R 3b are each independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl;
R 4 is selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl, each of the above R 4 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, ═O, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —NR 15 R 16 ;
R 5 is selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl;
R 6 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ;
R 7 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ;
R 8 and R 9 are each independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, and 3-6 membered heterocyclyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 3-6 membered heterocyclyl, each of the above R 8 and R 9 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —C 0-4 alkyl-NR 15 R 16 ;
or, R 5 and one of R 6 , R 7 , or R 9 , together with the moiety to which R 5 and one of R 6 , R 7 , or R 9 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ,
or, R 7 and R 8 , together with the moiety to which R 7 and R 8 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ,
or
is
and
R 10 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 .
5 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, —SF 5 , —O—R 13 , —O—C(O)R 14 , and —NR 15 R 16 , or R 1 and R 10 , together with the moiety to which R 1 and R 10 are directly attached, form a C 4-6 cycloalkyl or 4-6 membered heterocyclyl, each of the above R 1 or R 1 and adjacent R 10 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, ═O, —SF 5 , —S(O) r R 12 , —O—R 13 , —C(O)OR 13 , —C(O)R 14 , —O—C(O)R 14 , —NR 15 R 16 , —C(═NR 15 )R 14 , —N(R 15 )—C(═NR 16 )R 14 , —C(O)NR 15 R 16 , and —N(R 15 )—C(O)R 14 ;
R 2a and R 2b are each independently hydrogen, deuterium, C 1-4 alkyl, or C 3-6 cycloalkyl, or R 2a and R 2b , together with the carbon atom to which R 2a and R 2b are directly attached, form a C 3-6 cycloalkyl or 3-6 membered heterocyclyl, each of the above R 2a and R 2b groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl;
R 3a and R 3b are each independently selected from the group consisting of hydrogen, deuterium, halogen, C 1-4 alkyl, and C 3-6 cycloalkyl;
R 4 is hydrogen, deuterium, C 1-4 alkyl, or C 3-6 cycloalkyl, each of the above R 4 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, ═O, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyloxy, 3-6 membered heterocyclyl, 3-6 membered heterocyclyloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and —NR 15 R 16 ;
R 5 is selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl;
R 6 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl;
R 7 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl; and
R 8 and R 9 are each independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, and C 3-6 cycloalkyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 3-6 membered heterocyclyl, each of the above R 8 and R 9 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, and —NR 15 R 16 ;
or, R 5 and one of R 6 , R 7 , or R 9 , together with the moiety to which R 5 and one of R 6 , R 7 , or R 9 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, and C 3-6 cycloalkyl,
or, R 7 and R 8 , together with the moiety to which R 7 and R 8 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, and C 3-6 cycloalkyl,
or
is
R 10 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkenyl, C 2-4 alkynyl, and C 3-6 cycloalkyl.
6 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein each R 1 is independently selected from the group consisting of hydrogen, deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, oxacyclobutyl, azacyclobutyl, pyrazolyl, imidazolyl, oxazolyl, triazolyl, methoxy, amino, dimethylamino, and methylamino, or R 1 and R 10 , together with the moiety to which R 1 and R 10 are directly attached, form a cyclopentyl, each of the above R 1 or R 1 and adjacent R 10 groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, vinyl, ethynyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl; and
R 10 is selected from the group consisting of hydrogen, deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, vinyl, ethynyl, cyclopropyl, and cyclobutyl.
7 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein R 4 is selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, cyclopropyl, and cyclobutyl, each of the above R 4 groups optionally further substituted with one or more substituents independently selected from deuterium, fluoro, C 1-4 alkyl, and C 3-6 cycloalkyl.
8 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein R 2a and R 2b are each independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, cyclopropyl, and cyclobutyl, or R 2a and R 2b , together with the carbon atom to which R 2a and R 2b are directly attached, form a cyclopropyl, cyclobutyl, or cyclopentyl, each of the above R 2a and R 2b groups optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl.
9 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein R 3a and R 3b are each independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, cyclopropyl, and cyclobutyl.
10 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 4 , wherein R 5 is selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl;
R 6 is selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl;
R 7 is selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl; and
R 8 and R 9 are each independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 4-6 membered heterocyclyl;
or, R 5 and one of R 6 , R 7 , or R 9 , together with the moiety to which R 5 and one of R 6 , R 7 , or R 9 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, and C 3-6 cycloalkyl,
or, R 7 and R 8 , together with the moiety to which R 7 and R 8 are directly attached, form a 4-6 membered heterocyclyl, the 4-6 membered heterocyclyl optionally further substituted with one or more substituents independently selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, C 2-4 alkenyl, C 2-4 alkynyl, and C 3-6 cycloalkyl,
or
is
11 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof of claim 4 , wherein
is selected from the group consisting of:
wherein, each R 5 is independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, trideuteriomethyl, and dideuteriomethyl;
each R 6 is independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl;
R 7 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl,
each of R 8 and R 9 is independently selected from the group consisting of hydrogen, deuterium, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trideuteriomethyl, dideuteriomethyl, cyclopropyl, and cyclobutyl, or R 8 and R 9 , together with the nitrogen atom to which R 8 and R 9 are directly attached, form a 4-6 membered heterocyclyl;
R a is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl; and
R b is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuterioalkyl, and C 3-6 cycloalkyl.
12 . The compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 1 , wherein the compound is selected from the group consisting of:
13 . A pharmaceutical composition, comprising the compound of formula (I), or the stereoisomer or pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable carrier.