IP Library › Granted Patent US 12692292
Granted Patent B2
US 12692292 · App. 18/006,139 · Granted Jul 28, 2026

Molecular strategy to protect against desiccation

Inventors: Eric P Skaar (Nashville, TN); Erin Green (Nashville, TN)
Assignee: Vanderbilt University
C07K14/212C12N1/20C12N15/8201C12N2510/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12692292
App. No.
18/006,139
Granted
Jul 28, 2026
Kind
B2
Abstract

A composition, transgenic organism, and method of protecting against desiccation or heat are provided. The composition includes a DtpA protein and a heterologous biologic. The transgenic organism includes the nucleic acid sequence encoding the amino acid sequence of SEQ ID NO: 1. The method includes contacting a heterologous biologic or organism with a DtpA protein.

Claims (12)

1 . A composition, comprising:

a DtpA protein comprising the sequence of SEQ ID NO: 1; and

a heterologous protein.

2 . The composition of claim 1 , wherein the composition is solid.

3 . The composition of claim 1 , wherein the composition is liquid.

4 . The composition of claim 1 , wherein the DtpA protein is recombinantly expressed and added to the heterologous protein.

5 . The composition of claim 1 , wherein the DtpA protein and the heterologous protein are expressed in an organism that is not Acinetobacter baumannii.

6 . A method of protecting a heterologous protein against protein misfolding or aggregation, the method comprising contacting the heterologous protein with a DtpA protein comprising the sequence of SEQ ID NO: 1.

7 . The method of claim 6 , wherein the heterologous protein is an enzyme.

8 . The composition of claim 1 , wherein the heterologous protein is an enzyme.

9 . The composition of claim 1 , wherein a heterologous biologic selected from the group consisting of food and vaccine comprises the heterologous protein.

10 . The method of claim 6 , wherein a heterologous biologic selected from the group consisting of food and vaccine comprises the heterologous protein.