IP Library › Granted Patent US 12692371
Granted Patent B2
US 12692371 · App. 18/301,376 · Granted Jul 28, 2026

Hydrogel composition

Inventors: Szu-Hsien Chen (Taichung City, TW); Chiu-Fang Chen (Taichung City, TW); Ya-Wen Ku (Taichung City, TW); Ren-Shian Wang (Taichung City, TW)
Assignee: TRONJEN MEDICAL TECHNOLOGY INC.
C08L1/10C08K3/16C08K5/053C08K5/19C08K2201/014
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Quick Facts
Patent No.
US 12692371
App. No.
18/301,376
Granted
Jul 28, 2026
Kind
B2
Abstract

Disclosed herein is a hydrogel composition that includes a crosslinked collagen polymer, a carboxymethyl cellulose derivative, an aqueous sodium chloride solution, a humectant, and an antimicrobial agent. The crosslinked collagen polymer has collagen, a hydrophilic polyether, and a dicarbamate group linking the collagen to the hydrophilic polyether. The carboxymethyl cellulose derivative is selected from the group consisting of carboxymethyl cellulose, an alkali metal salt of carboxymethyl cellulose, an ammonium salt of carboxymethyl cellulose, and combinations thereof. The humectant is selected from the group consisting of glycerin, propylene glycol, and a combination thereof. The antimicrobial agent is a combination of glycine betaine and polyhexamethylene biguanide hydrochloride.

Claims (16)

1 . A hydrogel composition comprising:

a crosslinked collagen polymer that comprises a collagen, a hydrophilic polyether, and a dicarbamate group linking the collagen to the hydrophilic polyether, wherein a molar ratio of the collagen to the hydrophilic polyether ranges from 2:1 to 10:1;

a carboxymethyl cellulose derivative selected from the group consisting of carboxymethyl cellulose, an alkali metal salt of carboxymethyl cellulose, an ammonium salt of carboxymethyl cellulose, and a combination thereof;

an aqueous sodium chloride solution;

a humectant selected from the group consisting of glycerin, propylene glycol, and a combination thereof; and

an antimicrobial agent comprising a combination of glycine betaine and polyhexamethylene biguanide hydrochloride.

2 . The hydrogel composition as claimed in claim 1 , wherein the hydrophilic polyether is polyethylene glycol.

3 . The hydrogel composition as claimed in claim 1 , wherein the dicarbamate group is formed by:

(a) reacting the hydrophilic polyether with a diisocyanate to obtain a hydrophilic diisocyanate, the diisocyanate being selected from the group consisting of hexamethylene diisocyanate, dicyclohexylmethane-4,4′-diisocyanate (H 12 MDI), isophorone diisocyanate (IPDI), and combinations thereof; and

(b) reacting the collagen with the hydrophilic diisocyanate.

4 . The hydrogel composition as claimed in claim 1 , wherein the collagen is type I collagen.

5 . The hydrogel composition as claimed in claim 1 , wherein the crosslinked collagen polymer is present in an amount ranging from 0.5 wt % to 5 wt %, based on the total weight of the hydrogel composition.

6 . The hydrogel composition as claimed in claim 5 , wherein the crosslinked collagen polymer is present in an amount ranging from 2 wt % to 4 wt %, based on the total weight of the hydrogel composition.

7 . The hydrogel composition as claimed in claim 1 , wherein the humectant is present in an amount ranging from 1 wt % to 47.5 wt %, based on the total weight of the hydrogel composition.

8 . The hydrogel composition as claimed in claim 1 , wherein the carboxymethyl cellulose derivative is present in an amount ranging from 1 wt % to 10 wt %, based on the total weight of the hydrogel composition.

9 . The hydrogel composition as claimed in claim 1 , wherein the aqueous sodium chloride solution has a concentration ranging from 0.5 wt % to 1.0 wt %.