IP Library › Granted Patent US 12693288
Granted Patent B2
US 12693288 · App. 18/468,590 · Granted Jul 28, 2026

Quality control substance for use in the analysis of erythrocytes

Inventors: Kazuko Okumura (Kyoto, JP); Atsushi Nakao (Kyoto, JP); Kazuki Kudo (Kyoto, JP)
Assignee: ARKRAY, Inc.
G01N33/493G01N15/06G01N15/01G01N15/075
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Quick Facts
Patent No.
US 12693288
App. No.
18/468,590
Granted
Jul 28, 2026
Kind
B2
Abstract

The present disclosure provides a quality control substance for use in the analysis of erythrocytes, which can be prepared safely with easily available raw materials, which has an excellent preservation stability, and which can be used in the analysis of sediments in a sample. This quality control substance includes artificial particles whose form as observed with a microscope is similar to the form of erythrocytes as observed therewith.

Claims (12)

1 . A method for analyzing a sample using a urine sediment analyzer, comprising the steps of:

controlling measurement accuracy of the urine sediment analyzer with artificial particles whose form as observed with a microscope is similar to the form of erythrocytes as observed therewith, for measuring a concentration of erythrocytes in the sample; and

analyzing the sample with the urine sediment analyzer,

wherein the artificial particles are made of polymethylsilsesquioxane, wherein the artificial particles have an average particle size of from 2 μm to 6 μm, and wherein the artificial particles have a golf ball-like form or a raspberry-like form.

2 . The method according to claim 1 , wherein the color of the artificial particles as observed with the microscope is similar to the color of the erythrocytes as observed therewith.

3 . The method according to claim 1 , wherein the artificial particles are artificial particles included in at least one of raspberry-like, alumina microparticle-encapsulated polymethylsilsesquioxane particles or golf ball-like polymethylsilsesquioxane particles.

4 . A method for controlling a measurement accuracy of an analyzer that measures a concentration of particles whose form is similar to the form of erythrocytes in a sample, by counting the number of the particles in the sample, the method comprising the steps of:

measuring a concentration of particles in a quality control substance comprising artificial particles whose form is similar to the form of erythrocytes, using the analyzer, to obtain a measured value; and

determining the measurement accuracy of the analyzer by comparing the measured value with a reference value,

wherein the artificial particles are made of polymethylsilsesquioxane, wherein the artificial particles have an average particle size of from 2 μm to 6 μm, and wherein the artificial particles have a golf ball-like form or a raspberry-like form.

5 . The method according to claim 4 , wherein the color of the artificial particles as observed with a microscope is similar to the color of the erythrocytes as observed therewith.

6 . The method according to claim 4 , wherein the artificial particles are artificial particles included in at least one of raspberry-like, alumina microparticle-encapsulated polymethylsilsesquioxane particles or golf ball-like polymethylsilsesquioxane particles.