IP Library › Granted Patent US 12697035
Granted Patent B2
US 12697035 · App. 17/980,323 · Granted Aug 4, 2026

Lumen morphology and vascular resistance measurements data collection systems apparatus and methods

Inventors: Joseph M. Schmitt (Andover, MA); Joel M. Friedman (Andover, MA); Christopher Petroff (Groton, MA); Amr Elbasiony (Chelmsford, MA)
Assignee: LightLab Imaging, Inc.
A61B5/02007A61B5/0066A61B5/0073A61B5/0084
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Quick Facts
Patent No.
US 12697035
App. No.
17/980,323
Granted
Aug 4, 2026
Kind
B2
Abstract

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Claims (72)

1 . A method, comprising:

receiving, by one or more processors, vessel data including image data for a vessel;

determining, by the one or more processors based on the vessel data, a region of interest, the region of interest having a proximal end and a distal end;

generating, by the one or more processors based on the vessel data, a three-dimensional representation of the vessel;

determining, by the one or more processors based on the vessel data, diameter values for at least a portion of the vessel, wherein the portion of the vessel comprises the region of interest;

determining, by the one or more processors based on the diameter values, a location of a minimum lumen area or minimum diameter value within the region of interest;

generating, by the one or more processors based on the diameter values, a two-dimensional representation of the vessel;

determining, by the one or more processors based on the vessel data, pressure based measurements;

generating, by the one or more processors based on the pressure based measurements, a graphical representation of the pressure based measurements;

providing for output, by the one or more processors, the three-dimensional representation of the vessel, the two-dimensional representation of the vessel, and the graphical representation of the pressure based measurements, wherein:

the two-dimensional representation of the vessel comprises a first indicator corresponding to the proximal end of the region of interest, a second indicator corresponding to the distal end of the region of interest, and a third indicator corresponding to the location of the minimum lumen area or the minimum diameter value, and

the graphical representation of the pressure based measurements comprises a fourth indicator corresponding to the proximal end of the region of interest and a fifth indicator corresponding to the distal end of the region of interest;

receiving, by the one or more processors, a user input adjusting at least one of the first indicator or the second indicator longitudinally in representing a position along a length within the two-dimensional representation of the vessel, wherein the proximal end and the distal end of the region of interest define a predicted stent length;

determining, by the one or more processors based on the predicted stent length, a predicted post-stent lumen profile;

determining, by the one or more processors based on the predicted post-stent lumen profile, predicted pressure based measurements; and

providing for output, by the one or more processors, the predicted pressure based measurements.

2 . The method of claim 1 , wherein the pressure based measurements are pressure measurements for each point along the at least a portion of the vessel.

3 . The method of claim 2 , wherein at least one of the pressure based measurements is an arterial pressure or a venous pressure.

4 . The method of claim 1 , wherein the pressure based measurements are fractional flow reserve (FFR) measurements.

5 . The method of claim 1 , further comprising providing for output, by the one or more processors, an indication of the pressure based measurements.

6 . The method of claim 1 , wherein the image data includes at least one of optical coherence tomography (OCT) images or angiography images.

7 . The method of claim 1 , wherein the two-dimensional representation of the vessel includes an indication of the diameter values for the at least a portion of the vessel.

8 . A system, comprising:

one or more processors, the one or more processors configured to:

receive vessel data including image data for a vessel;

determine, based on the vessel data, a region of interest, the region of interest having a proximal end and a distal end;

generate, based on the vessel data, a three-dimensional representation of the vessel;

determine, based on the vessel data, diameter values for at least a portion of the vessel, wherein the portion of the vessel comprises the region of interest;

determine, based on the diameter values, a location of a minimum lumen area or minimum diameter value within the region of interest;

generate, based on the diameter values, a two-dimensional representation of the vessel;

determine, based on the vessel data, pressure based measurements;

generate, based on the pressure based measurements, a graphical representation of the pressure based measurements;

provide for output the three-dimensional representation of the vessel, the two- dimensional representation of the vessel, and the graphical representation of the pressure based measurements, wherein:

the two-dimensional representation of the vessel comprises a first indicator corresponding to the proximal end of the region of interest, a second indicator corresponding to the distal end of the region of interest, and a third indicator corresponding to the location of the minimum lumen area or the minimum diameter value, and

the graphical representation of the pressure based measurements comprises a fourth indicator corresponding to the proximal end of the region of interest and a fifth indicator corresponding to the distal end of the region of interest; and

receive a user input adjusting at least one of the first indicator or the second indicator longitudinally in representing a position along a length within the two-dimensional representation of the vessel, wherein the proximal end and the distal end of the region of interest define a predicted stent length;

determine, based on the predicted stent length, a predicted post-stent lumen profile;

determine, based on the predicted post-stent lumen profile, predicted pressure based measurements; and

provide for output the predicted pressure based measurements.

9 . The system of claim 8 , wherein the pressure based measurements are pressure measurements for each point along the at least a portion of the vessel.

10 . The system of claim 9 , wherein at least one of the pressure based measurements is an arterial pressure or a venous pressure.

11 . The system of claim 8 , wherein the pressure based measurements are fractional flow reserve (FFR) measurements.

12 . The system of claim 8 , wherein the one or more processors are further configured to provide for output an indication of the pressure based measurements.

13 . The system of claim 8 , wherein the image data includes at least one of optical coherence tomography (OCT) images or angiography images.

14 . The system of claim 8 , wherein the two-dimensional representation of the vessel includes an indication of the diameter values for the at least a portion of the vessel.

15 . A non-transitory computer-readable medium storing instructions, which when executed by one or more processors, cause the one or more processors to:

receive vessel data including image data for a vessel;

determine, based on the vessel data, a region of interest, the region of interest having a proximal end and a distal end;

generate, based on the vessel data, a three-dimensional representation of the vessel;

determine, based on the vessel data, diameter values for at least a portion of the vessel, wherein the portion of the vessel comprises the region of interest;

determine, based on the diameter values, a location of a minimum lumen area or minimum diameter value within the region of interest;

generate, based on the diameter values, a two-dimensional representation of the vessel;

determine, based on the vessel data, pressure based measurements;

generate, based on the pressure based measurements, a graphical representation of the pressure based measurements;

provide for output the three-dimensional representation of the vessel, the two-dimensional representation of the vessel, and the graphical representation of the pressure based measurements, wherein:

the two-dimensional representation of the vessel comprises a first indicator corresponding to the proximal end of the region of interest, a second indicator corresponding to the distal end of the region of interest, and a third indicator corresponding to the location of the minimum lumen area or the minimum diameter value, and

the graphical representation of the pressure based measurements comprises a fourth indicator corresponding to the proximal end of the region of interest and a fifth indicator corresponding to the distal end of the region of interest; and

receive a user input adjusting at least one of the first indicator or the second indicator longitudinally in representing a position along a length within the two-dimensional representation of the vessel, wherein the proximal end and the distal end of the region of interest define a predicted stent length;

determine, based on the predicted stent length, a predicted post-stent lumen profile;

determine, based on the predicted post-stent lumen profile, predicted pressure based measurements; and

provide for output the predicted pressure based measurements.

16 . The method of claim 1 , further comprising:

receiving, by the one or more processors, user input in connection with a first one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel; and

updating, by the one or more processors based on the user input received in connection with the first one, a second one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel.

17 . The method of claim 1 , wherein the region of interest corresponds to candidate region for treatment.

18 . The system of claim 8 , wherein the one or more processors are further configured to:

receive a user input in connection with a first one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel; and

update, based on the user input received in connection with the first one, a second one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel.

19 . The system of claim 8 , wherein the region of interest corresponds to candidate region for treatment.

20 . The non-transitory computer-readable medium of claim 15 , wherein the one or more processors are further configured to:

receive a user input in connection with a first one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel; and

update, based on the user input received in connection with the first one, a second one of the three-dimensional representation of the vessel or the two-dimensional representation of the vessel.