IP Library Granted Patent US 12697053
Granted Patent B2
US 12697053 · App. 18/449,623 · Granted Aug 4, 2026

Methods and systems for providing calibration point acceptance criteria for calibrating an analyte sensor

Inventors: Xiaoxiao Chen (Washington, DC); Andrew Dehennis (Germantown, MD); Srinivasan Rajaraman (Germantown, MD)
Assignee: Senseonics, Incorporated
A61B5/1495A61B5/0031A61B5/14503A61B5/14532A61B5/1459A61B5/150022A61B5/686A61B5/742G01N33/66G01N33/96A61B5/0004A61B5/0026A61B5/15142A61B2560/0223A61B2560/0252
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Quick Facts
Patent No.
US 12697053
App. No.
18/449,623
Granted
Aug 4, 2026
Kind
B2
Abstract

A method and transceiver for calibrating an analyte sensor using one or more reference measurements. In some embodiments, the method may include receiving a first reference analyte measurement (RM1) and determining whether the RM1 is unexpected. In some embodiments, the method may include, if the RM1 was determined to be unexpected, receiving a second reference analyte measurement (RM2). In some embodiments, the method may include determining whether one or more of the RM1 and the RM2 are acceptable as calibration points. In some embodiments, the method may include, if one or more of the RM1 and the RM2 are determined to be acceptable as calibration points, accepting one or more of the RM1 and the RM2 as calibration points. In some embodiments, the method may include calibrating the analyte sensor using at least one or more of the RM1 and the RM2 as calibration points.

Claims (63)

1 . An analyte monitoring method comprising:

using a light source of an analyte sensor of an analyte monitoring system to emit excitation light that interacts with indicator molecules of an analyte indicator of the analyte sensor;

using the indicator molecules of the analyte indicator with which the excitation light interacts to emit emission light;

using the analyte sensor to generate sensor data indicative of an amount or concentration of an analyte in proximity to the analyte indicator, wherein using the analyte sensor to generate the sensor data comprises using a photodetector of the analyte sensor to generate a measurement indicative of a level of the emission light emitted by the indicator molecules;

using a transceiver interface device of the analyte sensor to convey the sensor data;

using a sensor interface device of a transceiver of the analyte monitoring system to receive the sensor data conveyed by the analyte sensor;

using the transceiver to receive a first reference analyte measurement (RM1);

using a processor of the transceiver to determine that the RM1 is unexpected;

after determining that the RM1 is unexpected, using the transceiver to receive a second reference analyte measurement (RM2);

using the processor of the transceiver to use the sensor data to calculate a first sensor analyte measurement (SM1) without the RM1 as a calibration point;

using the processor of the transceiver to use the sensor data to calculate a second sensor analyte measurement (SM2) with the RM1 as a calibration point;

using the processor of the transceiver to determine that the RM2 is unexpected, wherein determining that the RM2 is unexpected comprises comparing the RM2 with the SM1 and comparing the RM2 with the SM2;

after determining that the RM2 is unexpected, using the transceiver to receive a third reference analyte measurement (RM3);

using the processor of the transceiver to accept one or more of the RM2 and the RM3 as calibration points; and

using the processor of the transceiver to calibrate the analyte sensor using at least one or more of the RM2 and the RM3 as calibration points.

2 . The method of claim 1 , further comprising, after determining that the RM2 is unexpected, accepting the RM1.

3 . The method of claim 1 , further comprising, after determining that the RM2 is unexpected, rejecting the RM1.

4 . The method of claim 1 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises accepting both the RM2 and the RM3 as calibration points.

5 . The method of claim 4 , wherein calibrating the analyte sensor uses at least the RM2 and the RM3 as calibration points.

6 . The method of claim 1 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises storing one or more of the RM2 and the RM3 in a calibration point memory.

7 . The method of claim 1 , wherein calibrating the analyte sensor comprises calibrating a conversion function used to convert sensor data received from the analyte sensor into a sensor analyte measurement.

8 . The method of claim 1 , wherein determining that the RM2 is unexpected comprises determining that a difference between the RM2 and the SM1 is not within a threshold amount and determining that a difference between the RM2 and the SM2 is not within a threshold amount.

9 . The method of claim 1 , further comprising:

using the analyte sensor to generate and convey second sensor data indicative of a second amount or concentration of the analyte in proximity to the analyte indicator of the analyte sensor;

using the transceiver to receive the second sensor data conveyed by the analyte sensor;

using the transceiver to use the second sensor data to calculate a third sensor analyte measurement (SM3) without the RM2 as a calibration point; and

using the transceiver to use the second sensor data to calculate a second fourth sensor analyte measurement (SM4) with the RM2 as a calibration point.

10 . The method of claim 9 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises:

determining that the difference between the RM3 and the SM3 is within a threshold amount; and

determining that the RM3 is closer to the SM3 than to the SM4.

11 . The method of claim 10 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises accepting the RM3 as a calibration point and not accepting the RM2 as a calibration point.

12 . The method of claim 11 , wherein calibrating the analyte sensor uses at least the RM3 as a calibration point and does not use the RM2 as a calibration point.

13 . An analyte monitoring system comprising:

an analyte sensor comprising:

an analyte indicator comprising indicator molecules;

a light source configured to emit excitation light that interacts with the indicator molecules;

a photodetector; and

a transceiver interface device, wherein the analyte sensor is configured to generate sensor data indicative of an amount or concentration of an analyte in proximity to the analyte indicator, generating the sensor data comprises using the photodetector to generate a measurement indicative of a level of emission light emitted by the indicator molecules, and the transceiver interface device is configured to convey the sensor data;

a transceiver comprising:

a sensor interface device configured to receive the sensor data conveyed by the analyte sensor; and

a display interface device configured to convey information to a display device and to receive information from the display device; and

a processor configured to:

receive a first reference analyte measurement (RM1) from the display device via the display interface device;

determine that the RM1 is unexpected;

after determining that the RM1 is unexpected, receive a second reference analyte measurement (RM2) from the display device via the display interface device;

use the sensor data to calculate a first sensor analyte measurement (SM1) without the RM1 as a calibration point;

use the sensor data to calculate a second sensor analyte measurement (SM2) with the RM1 as a calibration point;

determine that the RM2 is unexpected, wherein determining that the RM2 is unexpected comprises comparing the RM2 with the SM1 and comparing the RM2 with the SM2;

after determining that the RM2 is unexpected, receive a third reference analyte measurement (RM3) from the display device via the display interface device;

accept one or more of the RM2 and the RM3 as calibration points; and

calibrate the analyte sensor using at least one or more of the RM2 and the RM3 as calibration points.

14 . The analyte monitoring system of claim 13 , wherein the sensor interface device comprises an antenna configured to receive wirelessly the sensor data from the analyte sensor.

15 . The analyte monitoring system of claim 13 , wherein the analyte sensor is further configured to generate second sensor data indicative of a second amount or concentration of the analyte in proximity to the analyte indicator, and the processor is further configured to:

use the second sensor data to calculate a third sensor analyte measurement (SM3) without the RM2 as a calibration point; and

use the second sensor data to calculate a fourth sensor analyte measurement (SM4) with the the RM2 as a calibration point.

16 . The analyte monitoring system of claim 15 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises:

determining that the difference between the RM3 and the SM3 is within a threshold amount; and

determining that the RM3 is closer to the SM3 than to the SM4.

17 . The analyte monitoring system of claim 16 , wherein accepting one or more of the RM2 and the RM3 as calibration points comprises accepting the RM3 as a calibration point and not accepting the RM2 as a calibration point.

18 . The analyte monitoring system of claim 17 , wherein calibrating the analyte sensor uses at least the RM3 as a calibration point and does not use the RM2 as a calibration point.

19 . The analyte monitoring system of claim 13 , wherein the processor is further configured to, after determining that the RM2 is unexpected, accept the RM1.

20 . The analyte monitoring system of claim 13 , wherein the processor is further configured to, after determining that the RM2 is unexpected, reject the RM1.

21 . The analyte monitoring system of claim 13 , wherein the transceiver interface device comprises an inductor, and a sensor interface device comprises an inductor.