System and method for estimating a treatment volume for administering electrical-energy based therapies
The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
1 . A method of treating a lesion, the method comprising:
activating a generator to apply at least one test pulse to the lesion via an electrode;
activating the generator to administer an electrical energy based treatment via the electrode, including applying at least one treatment pulse to the lesion based on a measured response from the at least one test pulse, wherein the at least one treatment pulse has a higher voltage than the at least one test pulse;
wherein the generator is operably coupled to a processor and a display device, the processor for executing instructions stored in a non-transitory, computer readable medium, wherein the instructions, when executed, cause the processor to:
determine a baseline conductivity of the lesion from the application of the test pulse;
based at least in part on the baseline conductivity, determine a maximum conductivity expected during administration of the electrical energy based treatment;
monitor a parameter associated with the electrical energy based treatment, thereby monitoring a progress of the electrical energy based treatment;
determine a result of the electrical energy based treatment based on:
the maximum conductivity expected; and
the monitoring of the parameter associated with the electrical energy based treatment;
display, on the display device, the progress of the electrical energy based treatment in real-time; and
display, on the display device, the result of the electrical energy based treatment.
2 . The method of claim 1 , further comprising administering at least one non-electroporating pulse after the applying of the at least one treatment pulse.
3 . The method of claim 2 , further comprising measuring a response from the at least one non-electroporating pulse.
4 . The method of claim 3 , wherein the measured response from the at least one non-electroporating pulse is a measured electrical conductivity.
5 . The method of claim 1 , wherein the measured response from the at least one test pulse is a measured current.
6 . The method of claim 5 , further comprising estimating a target ablation zone based on the maximum conductivity expected.
7 . The method of claim 1 , wherein the monitoring of the progress includes monitoring a current value associated with the electrical energy based treatment.
8 . The method of claim 7 , wherein the monitoring of the progress includes monitoring a voltage value associated with the electrical energy based treatment.
9 . The method of claim 1 , wherein the monitoring of the progress includes monitoring a high current condition, a low current condition, a high voltage condition, or a low voltage condition.
10 . The method of claim 1 , further comprising determining whether the electrical energy based treatment was successful in ablating the lesion.
11 . A method of treating a lesion, the method comprising:
applying at least one test pulse to the lesion via an electrode;
measuring a response from the at least one test pulse, wherein the measured response includes an impedance value;
optimizing a treatment plan, based on the measured response, for an electrical energy based treatment, wherein the electrical energy based treatment includes at least one treatment pulse;
applying the at least one treatment pulse based on the optimized treatment plan;
determining a baseline conductivity of the lesion from the application of the test pulse;
determining a maximum conductivity expected during administration of the electrical energy based treatment;
monitoring a parameter associated with the electrical energy based treatment, thereby monitoring a progress of the electrical energy based treatment;
determining a result of the electrical energy based treatment based on;
the monitoring of the parameter associated with the electrical energy based treatment, wherein the determining includes determining whether the electrical energy based treatment was successful in ablating the lesion; and
a ratio of the maximum conductivity expected to the baseline conductivity;
displaying, on a display device, a progress of the electrical energy based treatment in real-time; and
displaying, on the display device, the result of the electrical energy based treatment in a manner in which indicates whether the electrical energy based treatment was successful or whether further treatment is necessary.
12 . The method of claim 11 , wherein the treatment plan includes an estimated treatment volume.
13 . The method of claim 11 , wherein the measured response is a measured current.
14 . The method of claim 13 , further comprising estimating a target ablation zone based on the maximum electrical conductivity expected.
15 . The method of claim 11 , wherein the monitoring of the progress includes monitoring an impedance value associated with the at least one treatment pulse.
16 . The method of claim 15 , wherein the at least one test pulse includes an AC voltage pulse and the at least one treatment pulse includes a DC voltage pulse delivered through the same electrode.
17 . The method of claim 11 , wherein the monitoring of the progress includes monitoring a current value associated with the electrical energy based treatment.
18 . The method of claim 17 , wherein the monitoring of the progress includes monitoring a voltage value associated with the electrical energy based treatment.
19 . The method of claim 17 , wherein the monitoring of the progress includes monitoring a high current condition, a low current condition, a high voltage condition, or a low voltage condition.