Pressurized goggle for intraocular pressure modification
Assemblies and methods for modifying an intraocular pressure of a patient's one or both eyes are disclosed. The assemblies and methods can be used to treat, inhibit, or prevent ocular conditions such as glaucoma, high intraocular pressure, optic disc edema, idiopathic intracranial hypertension, zero-gravity induced papilledema, and other optic pressure related conditions. An assembly can include a goggle including at least one cavity, a pump in fluid communication with the at least one cavity, and a control mechanism. The control mechanism can be operatively coupled to the pump and can maintain a target pressure or target pressure range in the at least one cavity, which, when the assembly is worn by a patient, is the area between a patient's eye(s) and wall surfaces of the goggle. Controlling the pressure over the outer surfaces of the patient's eye(s) can drive a desired change in the intraocular pressure of the eye(s).
1 . A pressure assembly to adjust cavity fluid pressure in a cavity to treat an eye condition of a patient based on a determined translaminar pressure gradient (TPG), the TPG being a pressure difference between biosensor-measured intraocular pressure (IOP) and separately and independently biosensor-measured cerebrospinal fluid pressure (CSFP), the cavity defined by an enclosure sized and shaped to fit over a patient eye without contacting a surface of the patient eye, the pressure assembly comprising:
control circuitry, configured to receive the biosensor-measured IOP and the separately and independently biosensor-measured CSFP and, based thereupon, to determine the TPG associated with the patient eye, and
a pressure source, configured to receive a control signal from the control circuitry and adjust the cavity fluid pressure toward a target IOP level in the patient eye based on the biosensor-measured IOP to equalize the determined TPG associated with the patient eye.
2 . The assembly of claim 1 , wherein the cavity fluid pressure is in a range of less than 0 mmHg gauge to about −40 mmHg gauge to treat glaucoma.
3 . The assembly of claim 1 , wherein the cavity fluid pressure is in a range of about −5 mmHg gauge to about −20 mmHg gauge.
4 . The assembly of claim 1 , wherein the cavity fluid pressure is in a range of greater than 0 mmHg gauge to about 40 mmHg gauge to treat ocular edema.
5 . The assembly of claim 1 , wherein the cavity fluid pressure is configured to vary over time.
6 . The assembly of claim 5 , wherein a cavity fluid pressure sequence is configured to vary based on a diurnal cycle.
7 . The assembly of claim 5 , wherein the cavity fluid pressure is configured to vary as a sequence over time.
8 . The assembly of claim 5 , wherein the cavity fluid pressure is varied as a sequence over time to increase a flow of an eye fluid through a trabecular meshwork in the patient eye.
9 . The assembly of claim 1 , wherein the cavity pressure is applied for a duration of time selected to treat the eye condition.
10 . The assembly of claim 9 , wherein the duration of time includes the duration being long enough to allow axonal transport to resume.
11 . The assembly of claim 1 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure in a range of less than 0 mmHg gauge to about −40 mmHg gauge to treat glaucoma.
12 . The assembly of claim 1 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure in a range of about −5 mmHg gauge to about −20 mmHg gauge.
13 . The assembly of claim 1 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure in a range of greater than 0 mmHg gauge to about 40 mmHg gauge to treat ocular edema.
14 . The assembly of claim 1 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure being configured to vary over time.
15 . The assembly of claim 14 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish a cavity fluid pressure sequence that is configured to vary based on a diurnal cycle.
16 . The assembly of claim 14 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure is configured to vary as a sequence over time.
17 . The assembly of claim 14 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity fluid pressure that is varied as a sequence over time to increase a flow of an eye fluid through a trabecular meshwork in the patient eye.
18 . The assembly of claim 1 , wherein the pressure control mechanism includes a pressure source controlled by control circuitry to establish the cavity pressure that is applied for a duration of time selected to treat the eye condition.
19 . The assembly of claim 18 , wherein the duration of time includes the duration required to allow axonal transport to resume.
20 . A pressure assembly to adjust fluid pressure in a cavity to treat an eye condition of a patient, based on a determined translaminar pressure gradient (TPG), the TPG being a pressure difference between biosensor-measured intraocular pressure (IOP) in the patient eye and separately and independently biosensor-measured cerebrospinal fluid pressure (CSFP) in the patient, the cavity defined by an enclosure sized and shaped to fit over a patient eye without contacting a surface of the patient eye, the pressure assembly comprising:
a pressure control mechanism including control circuitry configured to receive the biosensor-measured IOP and the separately and independently biosensor-measured CSFP and, based thereupon, to determine the TPG associated with the patient eye and to provide a control signal based thereupon to adjust the cavity fluid pressure toward a target IOP level in the patient eye based on the biosensor-measured IOP to equalize the determined TPG.