Implantable isoxazoline pharmaceutical compositions and uses thereof
An implant for the control of parasites in livestock comprising an isoxazoline compound of Formula (I) or salt or solvate thereof, wherein the implant comprises one or more pellets each of which comprises the isoxaxoline compound and a pharmaceutically acceptable excipient and a method of preventing or treating a parasite infestation using the same.
1 . A method of treating a parasite infestation in livestock animals comprising administering an implant to animals in need thereof wherein the implant comprises
one or more immediate release pellets and one or more delayed release pellets, wherein the ratio of the immediate release pellets and the delayed release pellets is between 1:10 and 10:1 and wherein
a) the immediate release pellets comprise
i) fluralaner
ii) diluent;
iii) binder and
iv) micronized intragranular poloxamer, and
b) the delayed release pellets comprise
i) fluralaner
ii) diluent, and
iii) binder;
wherein the delayed release pellets are coated with a biodegradable polymer.
2 . The method of claim 1 , wherein the implant is effective for at least 3 months.
3 . The method of claim 1 , wherein the diluent is lactose.
4 . The method of claim 1 , wherein the binder is povidone.
5 . The method of claim 1 , wherein the percentage of fluralaner in each pellet is between about 50% w/w to about 90% w/w.
6 . The method of claim 1 , wherein the ratio of the immediate release pellets to delayed release pellets is about 1:1.
7 . The method of claim 1 , wherein the biodegradable polymer is chosen from poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL).
8 . The method of claim 1 , wherein the biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA) and the ratio of the lactic acid and glycolic acid monomers in the PLGA is about 50:50 to about 90:10.
9 . The method of claim 1 , wherein the delayed release pellets are coated with PLGA 65:35.