Composition for treating brain disease comprising
A composition which contains Pediococcus inopinatus , a culture, a lysate, an extract or a fermented product thereof, or extracellular vesicles isolated therefrom as an active ingredient, and its uses are disclosed. The composition inhibits neuroinflammation, which is a cause of a degenerative brain disease, or reduces cell death caused by oxidative stress and Amyloid β accumulation. Therefore, the composition can be utilized as an agent for preventing, ameliorating or treating various degenerative brain diseases including Alzheimer's disease and stroke. Accordingly, a method for preventing, ameliorating or treating a brain disease, by administering the composition to a subject in need thereof is disclosed.
1 . A method for alleviating a brain disease in a subject in need thereof, comprising administering a therapeutically effective amount of extracellular vesicles derived from the Pediococcus inopinatus or a culture thereof, to the subject, wherein the brain disease is one or more disease selected from the group consisting of Parkinson's disease, Alzheimer's disease, Huntington's disease, Lou Gehrig's disease (amyotrophic lateral sclerosis), stroke, multiple sclerosis, learning disorder, cognitive impairment, neuroinflammation, neuronal damage, and memory impairment.
2 . The method according to claim 1 , wherein the Pediococcus inopinatus is Pediococcus inopinatus WIKIM27 (accession number KCCM12653P).
3 . The method according to claim 1 , wherein the brain disease is neuroinflammation.
4 . The method according to claim 1 , wherein the brain disease is neuronal damage.
5 . The method according to claim 1 , wherein the brain disease is memory impairment.
6 . The method according to claim 1 , wherein the brain disease is learning disorder, cognitive impairment or Alzheimer's disease.
7 . A method for preparing a composition for alleviating a brain disease, comprising:
(a) preparing a Pediococcus inopinatus strain;
(b) culturing the strain in a culture medium; and
(c) separating extracellular vesicles from the strain or the culture medium,
wherein the brain disease is one or more disease selected from the group consisting of Parkinson's disease, Alzheimer's disease, Huntington's disease, Lou Gehrig's disease (amyotrophic lateral sclerosis), stroke, multiple sclerosis, learning disorder, cognitive impairment, neuroinflammation, neuronal damage, and memory impairment.
8 . A method for preparing a composition for alleviating a brain disease, comprising preparing extracellular vesicles derived from Pediococcus inopinatus or a culture thereof,
wherein the brain disease is one or more disease selected from the group consisting of Parkinson's disease, Alzheimer's disease, Huntington's disease, Lou Gehrig's disease (amyotrophic lateral sclerosis), stroke, multiple sclerosis, learning disorder, cognitive impairment, neuroinflammation, neuronal damage, and memory impairment.