Method for coating implant using heat
Provided is a method for coating an implant using heat, and more particularly to a method for coating only the surface of an implant with a biocompatible polymer by using heat while maintaining physical characteristics of the implant. The method for coating an implant using heat according to the present invention may effectively introduce a biocompatible polymer onto a three-dimensional material surface and thus may overcome the spatial limitations of light, and enables mass-coating and thus may be effectively used in the manufacture of an implant coated with a biocompatible polymer.
1 . A method for coating a breast implant for the reconstruction of breast or aesthetic augmentation, the method comprising:
allowing a thermal initiator and a first crosslinking agent to adsorb onto the implant and then drying the thermal initiator and the first crosslinking agent adsorbed on the implant, wherein the thermal initiator is selected from the group consisting of benzoyl peroxide (BPO), lauroyl peroxide, tert-butyl hydroperoxide, and cumene hydroperoxide (CHP); and
after drying, adding a solution comprising an acrylate group-containing amphoteric monomer and a second crosslinking agent to the implant adsorbed with the thermal initiator and the first crosslinking agent and applying heat thereto,
wherein the implant comprises a surface material selected from the group consisting of polydimethylsiloxane (PDMS), hydroxyapatite (HA), polylactic acid (PLA), polyglycolic acid (PGA), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), polypropylene, polyamide, polyacetal, polyester, and polymethyl methacrylate,
wherein the coating is formed by covalent bonds between acrylate groups of the acrylate group-containing amphoteric monomer and the surface material of the implant,
wherein the coating provides strong hydrogen bonds with water molecules via its cationic and anionic charges to form a hydrated layer,
wherein the concentration of the second crosslinking agent within the solution ranges from 0.01 mol % to 2.0 mol % relative to the amphoteric monomer,
wherein heat is applied for 1 to 18 hours,
wherein the first crosslinking agent and the second crosslinking agent are different and each independently selected from the group consisting of dipentaerythritol pentaacrylate, dipentaerythritol hexaacrylate, ethyleneglycol dimethacrylate, and a combination thereof,
wherein the thermal initiator is used in an amount of 20 mol % to 50 mol % based on the acrylate group-containing amphoteric monomer,
wherein the acrylate group-containing amphoteric monomer comprises at least one monomer selected from the group consisting of methacryloyloxyethyl phosphorylcholine (MPC), acryloyloxyethyl phosphorylcholine (APC), and carboxybetaine acrylate, and
wherein the heat is applied at a temperature of 60° C. to 95° C.
2 . The method of claim 1 , wherein the step of allowing the thermal initiator and the first crosslinking agent to adsorb onto the implant comprises immersing the implant in a solution of the thermal initiator and the first crosslinking agent.
3 . The method of claim 1 , wherein the step of adding the solution comprising the acrylate group-containing amphoteric monomer and a second crosslinking agent to the implant adsorbed with the thermal initiator and the first crosslinking agent comprises immersing the implant adsorbed with the thermal initiator and the first crosslinking agent in a solution of the acrylate group-containing amphoteric monomer and the second crosslinking agent.
4 . The method of claim 3 , wherein heat is applied to the implant adsorbed with the thermal initiator and the first crosslinking agent while in the solution of the acrylate group-containing amphoteric monomer and the second crosslinking agent.
5 . A method for coating a breast implant for the reconstruction of breast or aesthetic augmentation, the method comprising:
allowing a thermal initiator and a first crosslinking agent to adsorb onto the implant and then drying the thermal initiator and the first crosslinking agent adsorbed on the implant, wherein the thermal initiator is benzoyl peroxide (BPO); and
after drying, adding a solution comprising an acrylate group-containing amphoteric monomer and a second crosslinking agent to the implant adsorbed with the thermal initiator and the first crosslinking agent and applying heat thereto,
wherein the implant comprises a surface material selected from the group consisting of polydimethylsiloxane (PDMS), hydroxyapatite (HA), polylactic acid (PLA), polyglycolic acid (PGA), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), polypropylene, polyamide, polyacetal, polyester, and polymethyl methacrylate,
wherein the coating is formed by covalent bonds between acrylate groups of the acrylate group-containing amphoteric monomer and the surface material of the implant,
wherein the coating provides strong hydrogen bonds with water molecules via its cationic and anionic charges to form a hydrated layer,
wherein the concentration of the second crosslinking agent within the solution ranges from 0.01 mol % to 2.0 mol % relative to the amphoteric monomer,
wherein heat is applied for 1 to 18 hours,
wherein the first crosslinking agent and the second crosslinking agent are different and each independently selected from the group consisting of dipentaerythritol pentaacrylate, dipentaerythritol hexaacrylate, and a combination thereof,
wherein the thermal initiator is used in an amount of 20 mol % to 50 mol % based on the acrylate group-containing amphoteric monomer,
wherein the acrylate group-containing amphoteric monomer comprises at least one monomer of methacryloyloxyethyl phosphorylcholine (MPC), and
wherein the heat is applied at a temperature of 60° C. to 95° C.
6 . The method of claim 5 wherein the step of allowing the thermal initiator and the first crosslinking agent to adsorb onto the implant comprises immersing the implant in a solution of the thermal initiator and the first crosslinking agent.
7 . The method of claim 5 wherein the step of adding the solution comprising the acrylate group-containing amphoteric monomer and a second crosslinking agent to the implant adsorbed with the thermal initiator and the first crosslinking agent comprises immersing the implant adsorbed with the thermal initiator and the first crosslinking agent in a solution of the acrylate group-containing amphoteric monomer and the second crosslinking agent.
8 . The method of claim 7 , wherein heat is applied to the implant adsorbed with the thermal initiator and the first crosslinking agent while in the solution of the acrylate group-containing amphoteric monomer and the second crosslinking agent.