Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
View Patent ↗A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
1 . An apparatus comprising:
a wrap comprising first and second layers;
wherein the first layer includes a desiccated, translucent, amorphous hydrogel film, the hydrogel film comprising hyaluronic acid and sodium alginate;
wherein the second layer includes collagen;
wherein the first layer is fused to the second layer;
wherein the first layer has at least 1% hyaluronic acid by dry weight.
2 . The apparatus of claim 1 , wherein the hyaluronic acid is uncrosslinked.
3 . The apparatus of claim 2 , wherein the sodium alginate in the first layer is uncross-linked.
4 . The apparatus of claim 3 , wherein the first layer includes no more than 33% hyaluronic acid by dry weight.
5 . The apparatus of claim 4 , wherein the first and second layers are both flat and planar.
6 . The apparatus of claim 4 , wherein the hydrogel film consists essentially of the hyaluronic acid and the sodium alginate.
7 . The apparatus of claim 4 , wherein the hydrogel film is unpatterned on at least one surface of the hydrogel film.
8 . The apparatus of claim 7 , wherein the first layer has a degree of bioabsorbability based on a ratio of the hyaluronic acid to the sodium alginate.
9 . The apparatus of claim 8 , wherein the hydrogel film is flat and includes a width, a length, and a thickness that is less than the width and the length.
10 . The apparatus of claim 8 , wherein the hydrogel film includes an anionic polymer.
11 . The apparatus of claim 10 , wherein the first layer is negatively charged.
12 . The apparatus of claim 11 , wherein the hydrogel film is non-synthetic.
13 . The apparatus of claim 12 , wherein the hydrogel film is a cast film.
14 . The apparatus of claim 12 , wherein the first layer is hydrophilic.
15 . The apparatus of claim 14 , wherein the first layer is anti-adhesive and non-attractive to cells.
16 . The apparatus of claim 15 , wherein the second layer is adhesive to cells.
17 . The apparatus of claim 16 , wherein the first layer is non-cytotoxic.