IP Library Granted Patent US 12697502
Granted Patent B2
US 12697502 · App. 17/921,563 · Granted Aug 4, 2026

Kilohertz transcranial magnetic perturbation with temporal interference

Inventors: Daniel J. Sheltraw (Albany, CA); Benjamin A. Inglis (Lafayette, CA); Richard Irwin Ivry (El Cerrito, CA); Ludovica Labruna (Kensington, CA)
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
A61N2/006A61N1/40A61N2/02
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Quick Facts
Patent No.
US 12697502
App. No.
17/921,563
Granted
Aug 4, 2026
Kind
B2
Abstract

A magnetic stimulation system has at least two magnetic coils, each coil to generate an induced electric field of a magnitude having a desired effect on a brain, at least two frequency controllers, wherein each coil is electrically connected to a corresponding frequency controller, the frequency controllers to adjust a frequency of power supplied to the corresponding coils according to a desired interference pattern, and at least one power source to provide power to the frequency controllers corresponding to each coil. A method of operating a magnetic stimulation system includes generating two or more signals to apply to two or more coils, each signal corresponding to one of the at least two coils, wherein at least two coils receive different signals and the different signals differ at least in frequency according to a desired temporal interference pattern.

Claims (21)

1 . A magnetic stimulation system, comprising:

at least two magnetic coils, each coil to generate an electric field of a magnitude having a desired effect on a brain;

at least two frequency controllers, wherein each coil is electrically connected to a corresponding frequency controller, the frequency controllers to adjust a frequency of power supplied to the corresponding coils according to a desired interference pattern;

at least one power source to provide power to the frequency controllers corresponding to each coil; and

a controller to control the at least one power source and the frequency controllers corresponding to each coil to apply continuous current waveforms to each coil according to the desired interference pattern between the at least two coils.

2 . The magnetic stimulation system as claimed in claim 1 , wherein the at least two frequency controllers comprise frequency synthesizers and the at least one power source comprises at least two voltage to current sources, each coil having a corresponding voltage to current source.

3 . The magnetic stimulation system as claimed in claim 1 , wherein the controller is configurable to operate the coils with amplitude modulation.

4 . The magnetic stimulation system as claimed in claim 1 , wherein the controller is configurable to operate the frequency controllers at different frequencies.

5 . The magnetic stimulation system as claimed in claim 1 , wherein the at least two frequency controllers and the at least one power source comprise at least two transformers establishing a fixed interference pattern, and the at least one power source comprises a power supply.

6 . The magnetic stimulation system as claimed in claim 1 , wherein the magnetic coils are one of circular or figure-8 or a geometry appropriate to generation of a focal electric field response in the brain.

7 . A method of operating a magnetic stimulation system, comprising:

generating two or more different signals to apply to two or more coils using frequency controllers corresponding to each coil, the frequency controllers to adjust a frequency of power supplied to the corresponding coils according to a desired interference pattern; and

using a controller to control at least one power source providing power to the two or more coils and the frequency controllers corresponding to each coil, and to apply continuous current waveforms to each coil according to the desired interference pattern between the two or more coils.

8 . The method as claimed in claim 7 , wherein the different signals differ in frequency by a percentage of a carrier frequency.

9 . The method as claimed in claim 7 , wherein generating the two or more different signals comprises generating temporal interference at a desired frequency.

10 . The method as claimed in claim 9 , wherein generating temporal interference signals comprises controlling the frequency of the two or more signals to adjust a focal location of magnetic energy.

11 . The method as claimed in claim 7 , wherein generating the two or more signals comprises:

using the controller to provide a signal to the frequency controllers to generate two or more different signals as two or more signals of different frequencies; and

sending each of the two or more signals of different frequencies to a corresponding voltage to current source connected to each of the two or more coils.

12 . The method as claimed in claim 7 , wherein generating the two or more different signals comprises:

using at least two transformers, each transformer corresponding to one of the two or more coils, each transformer to control the frequency of one of the two or more signals sent to each of the corresponding coils according to a desired temporal interference pattern between the at least two coils.