IP Library › Granted Patent US 12698341
Granted Patent B2
US 12698341 · App. 18/652,669 · Granted Aug 4, 2026

Antigen binding domains that bind to mesothelin (MSLN)

Inventors: John R. Desjarlais (Pasadena, CA); Matthew Bernett (Monrovia, CA); Michael Hedvat (Encino, CA); Veronica Gusti Zeng (Monrovia, CA); Matthew S. Faber (Monrovia, CA)
Assignee: Xencor, Inc.
C07K16/3069C07K16/2809A61K39/00C07K2317/31C07K2317/56C07K2317/565C07K2317/622
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Quick Facts
Patent No.
US 12698341
App. No.
18/652,669
Granted
Aug 4, 2026
Kind
B2
Abstract

The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Mesothelin (MSLN).

Claims (6)

1 . A mesothelin (MSLN) antigen binding domain comprising a variable heavy domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 241 and a variable light domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 245.

2 . The MSLN antigen binding domain according to claim 1 , wherein said variable heavy domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 241 and said variable light domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 245.

3 . The MSLN antigen binding domain according to claim 1 , wherein said variable heavy domain has the amino acid sequence of SEQ ID NO: 241, and said variable light domain has the amino acid sequence of SEQ ID NO: 245.

4 . An antibody comprising a mesothelin (MSLN) antigen binding domain comprising a variable heavy domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 241 and a variable light domain having at least 90% identity to the amino acid sequence of SEQ ID NO: 245.

5 . The antibody comprising the MSLN antigen binding domain according to claim 4 wherein said variable heavy domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 241 and said variable light domain has at least 95% identity to the amino acid sequence of SEQ ID NO: 245.

6 . The antibody comprising the MSLN antigen binding domain according to claim 4 , wherein said variable heavy domain has the amino acid sequence of SEQ ID NO: 241, and said variable light domain has the amino acid sequence of SEQ ID NO: 245.