Integrated system for preparation of pathology samples
An integrated pathology system includes a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block, a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides, a staining module configured to stain the one or more tissue sections on the slides, and a cover-slipper module configured to place a cover onto the one or more stained tissue sections. The system further includes one or more transfer devices configured to integrate the modules and a processor in communication with the modules for controlling one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.
1 . An integrated pathology system comprising:
a tissue embedding module configured to embed a tissue sample into an embedding material to prepare a tissue block;
a sectioning and slide creating module configured to remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides;
a staining module configured to stain the one or more tissue sections on the one or more slides;
a cover-slipper module configured to place a cover onto the one or more stained tissue sections;
one or more transfer devices configured to integrate the modules, wherein:
the one or more transfer devices comprise a pick-and-place robot; and
the modules are positioned radially around the pick-and-place robot; and
a processor in communication with the modules and being programmed to control one or more processes performed by the modules and the one or more transfer devices for controlling the integration of the modules.
2 . The integrated pathology system of claim 1 further comprising an imaging module configured to image the one or more covered tissue sections.
3 . The integrated pathology system of claim 1 further comprising a tissue processing module or station configured to fix a tissue in formalin.
4 . The integrated pathology system of claim 1 further comprising a tissue grossing module or station configured to receive and process a tissue sample before transporting the tissue sample to the tissue embedding module.
5 . The integrated pathology system of claim 1 further comprising systems to check and verify tissue quality and enable tissue tracking throughout the system.
6 . The integrated pathology system of claim 1 , wherein the processor is further programmed track the tissue sample through the one or more processes.
7 . A method, comprising:
automatedly embedding a tissue sample into an embedding material to prepare a tissue block at a tissue embedding module;
automatedly transporting the tissue block from the tissue embedding module to a sectioning and slide creating module where one or more tissue sections are automatedly removed from the tissue block and placed onto one or more slides;
automatedly transporting the one or more tissue sections on the one or more slides from the sectioning and slide creating module to a staining module where the one or more tissue sections on the one or more slides are stained; and
automatedly transporting one or more stained tissue sections from the staining module to a cover-slipper module where a cover is placed onto the one or more stained tissue sections, wherein:
the automatedly transporting comprises moving, with a pick-and-place robot, an output from at least one of the tissue embedding module, the sectioning and slide creating module, or the staining module, to at least one of the sectioning and slide creating module, the staining module, or the cover-slipper module; and
the tissue embedding module, the sectioning and slide creating module, the staining module, and the cover-slipper module are positioned radially around the pick-and-place robot.
8 . The method of claim 7 , further comprising automatedly transporting one or more covered tissue sections from the cover-slipper module to an imaging module where the one or more covered tissue sections are imaged.
9 . The method of claim 7 , further comprising fixing a tissue sample in formalin at a tissue processing module.
10 . The method of claim 9 , further comprising automatedly transporting the tissue sample fixed in formalin from the tissue processing module to the tissue embedding module where the tissue sample is embedded into an embedding material to prepare a tissue block.
11 . The method of claim 9 , further comprising receiving and processing the tissue sample at a tissue grossing module before transporting the tissue sample to the tissue processing module.
12 . A system comprising:
a plurality of modules configured to:
embed a tissue sample into an embedding material to prepare a tissue block;
remove one or more tissue sections from the tissue block and place the one or more tissue sections onto one or more slides;
stain the one or more tissue sections on the one or more slides; and
place a cover onto the one or more stained tissue sections;
a pick-and-place robot configured to integrate the plurality of modules, wherein the plurality of modules are positioned radially around the pick-and-place robot in a star-shaped structure; and
a processor communicatively coupled to each of the plurality of modules and being programmed to:
instruct the plurality of modules to implement a processing protocol for the tissue sample; and
track the tissue sample through the plurality of modules.
13 . The system of claim 12 , wherein the processor is further configured to identify a tissue sample.
14 . The system of claim 12 , wherein the processor is further configured to assign a unique identifier to each of the one or more tissue sections.
15 . The system of claim 12 , wherein the processor is further configured to generate a processing status for each of the one or more tissue sections as each of the one or more tissue sections is passed through the plurality of modules.
16 . The system of claim 12 , wherein the processor is further configured provide analytics about a throughput of the system.
17 . The system of claim 12 , wherein the plurality of modules comprise:
a tissue embedding module configured to embed the tissue sample into an embedding material to prepare a tissue block;
a sectioning and slide creating module configured to remove the one or more tissue sections from the tissue block and place the one or more tissue sections onto the one or more slides;
a staining module configured to stain the one or more tissue sections on the one or more slides; and
a cover-slipper module configured to place the cover onto the one or more stained tissue sections.
18 . The system of claim 12 , further comprising an imaging module configured to image one or more covered tissue sections.
19 . The system of claim 12 , further comprising a tissue processing module configured to fix a tissue in formalin.
20 . The system of claim 19 , further comprising a tissue grossing module configured to receive and process a tissue sample before transporting the tissue sample to the tissue processing module.
21 . The system of claim 12 , wherein the processor is communicatively coupled to the pick-and-place robot and further programmed to instruct the pick-and-place robot to move an output from at least one of the plurality of modules to at least one other of the plurality of modules.