Composition containing TARC, and method for improving storage stability of TARC
An object of the present invention is to provide a TARC-containing composition with high storage stability. Provided is a composition including TARC (Thymus and activation-regulated chemokine) and one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant and being in liquid form. The aforementioned object is achieved by the composition.
1 . A composition comprising:
TARC (Thymus and activation-regulated chemokine); and
one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant, and
being in liquid form,
wherein the TARC concentration is 100 μg/mL to 50 ng/ml with respect to the composition, and
wherein the composition is filled in a storage container.
2 . The composition according to claim 1 , wherein the composition is a calibration sample solution for measuring TARC.
3 . The composition according to claim 1 , wherein the storage container is plastic.
4 . The composition according to claim 1 , wherein the concentration of the one or more selected from the group consisting of the sugar fatty acid ester-type nonionic surfactant, the polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and the polyoxyethylene alkylamine-type nonionic surfactant is 0.00001 mass % to 1 mass % with respect to the composition.
5 . The composition according to claim 1 , wherein the sugar fatty acid ester-type nonionic surfactant is a polyoxyethylene sorbitan fatty acid ester-type nonionic surfactant.
6 . The composition according to claim 1 , wherein when the TARC concentration is 500 μg/mL with respect to the composition, the TARC residual rate is 80% or more after storage at 37° C. for 28 days in a plastic container.
7 . The composition according to claim 1 , wherein when the TARC concentration is 500 μg/mL with respect to the composition, the TARC residual rate is 90% or more after storage at 4° C. for 28 days in a plastic container.
8 . The composition according to claim 1 , wherein the sugar fatty acid ester-type nonionic surfactant is polyoxyethylene (20) sorbitan monolaurate, or polyoxyethylene (20) sorbitan monooleate; the polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant is polyoxyethylene-polyoxypropylene condensate; and the polyoxyethylene alkylamine-type nonionic surfactant is polyoxyethylene (20) cured tallow amine.
9 . A kit for measuring TARC, wherein the kit comprises the composition according to claim 1 .
10 . A method for improving storage stability of TARC, comprising a step of contacting TARC with a solution containing one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant,
wherein the TARC concentration is adjusted so as to be 100 μg/mL to 50 ng/ml with respect to the solution.
11 . The method for improving the storage stability of TARC according to claim 10 , wherein a concentration of the one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant in the solution is 0.00001 mass % to 1 mass % with respect to the solution.
12 . The method for improving the storage stability of TARC according to claim 10 , wherein the sugar fatty acid ester-type nonionic surfactant is a polyoxyethylene sorbitan fatty acid ester-type nonionic surfactant.
13 . The method for improving the storage stability of TARC according to claim 10 , wherein the sugar fatty acid ester-type nonionic surfactant is polyoxyethylene (20) sorbitan monolaurate, or polyoxyethylene (20) sorbitan monooleate; the polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant is polyoxyethylene-polyoxypropylene condensate; and the polyoxyethylene alkylamine-type nonionic surfactant is polyoxyethylene (20) cured tallow amine.
14 . A method for preventing adsorption of TARC in a solution containing TARC onto a container, comprising:
a step of adding a TARC adsorption inhibitor containing one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant, as active component, to the container, and
a step of adding TARC to the container.
15 . The method according to claim 14 , wherein the sugar fatty acid ester-type nonionic surfactant is a polyoxyethylene sorbitan fatty acid ester-type nonionic surfactant.
16 . The method according to claim 14 , wherein the sugar fatty acid ester-type nonionic surfactant is polyoxyethylene (20) sorbitan monolaurate, or polyoxyethylene (20) sorbitan monooleate; the polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant is polyoxyethylene-polyoxypropylene condensate; and the polyoxyethylene alkylamine-type nonionic surfactant is polyoxyethylene (20) cured tallow amine.