System for treating embolism and associated devices and methods
Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.
1 . A blood filtering system, comprising:
a container, wherein—
in a first state of the container, the container is attached to an aspiration catheter assembly, fluidly coupled to an aspiration catheter of the aspiration catheter assembly, and configured to receive blood and clot material aspirated from a vasculature of a patient through the aspiration catheter, and
in a second state of the container, the container is detached from the aspiration catheter assembly and fluidly decoupled from the aspiration catheter;
a filter device comprising:
a housing defining a chamber;
an inlet, wherein in a third state of the container, the container is attached to the inlet and fluidly coupled to the inlet to provide the blood and the clot material to the inlet;
an outlet;
a fluid path extending from the inlet, through the chamber, and to the outlet; and
a filter positioned in the chamber along the fluid path and configured to (a) permit the blood to flow therethrough along the fluid path from the inlet to the outlet and (b) inhibit the clot material from flowing therethrough along the fluid path from the inlet to the outlet; and
a syringe, wherein—
in a first state of the syringe, the syringe is attached to the outlet, fluidly coupled to the outlet, and actuatable to draw the filtered blood through the outlet,
in a second state of the syringe, the syringe is detached from the outlet and fluidly decoupled from the outlet.
2 . The blood filtering system of claim 1 wherein the syringe is a first syringe, and wherein the container is a second syringe.
3 . The blood filtering system of claim 1 wherein the container is a vacuum-pressure locking syringe.
4 . The blood filtering system of claim 1 wherein the filter is a first filter, and wherein the filter device further comprises a second filter configured to (a) further permit the blood to flow therethrough along the fluid path from the inlet to the outlet and (b) further inhibit the clot material from flowing therethrough along the fluid path from the inlet to the outlet.
5 . The blood filtering system of claim 4 wherein the second filter is positioned in the chamber between the first filter and the outlet.
6 . The blood filtering system of claim 5 wherein the first filter has a first porosity, and wherein the second filter has a second porosity smaller than the first porosity.
7 . The blood filtering system of claim 4 wherein the housing is a first housing, wherein the chamber is a first chamber, wherein the filter device further comprises a second housing, wherein the second filter is positioned in the second housing, and wherein the second housing includes the outlet.
8 . The blood filtering system of claim 1 wherein the inlet has an inlet inner diameter, and wherein the outlet has an outlet inner diameter less than the inlet diameter.
9 . The blood filtering system of claim 1 wherein the filter device further comprises a cap coupled to the housing, wherein the outlet is coupled to the cap, and wherein the cap is removable from the housing to provide access to the filter.
10 . The blood filtering system of claim 1 wherein the inlet comprises at least one tube and a fluid control device, wherein the fluid control device is movable between (a) a first position in which the inlet is fluidly connected to the chamber and (b) a second position in which the inlet is fluidly disconnected from the chamber.
11 . The blood filtering system of claim 1 wherein, in a third state of the syringe, the syringe is attached to a reinfusion catheter assembly including a reinfusion catheter and fluidly coupled to the reinfusion catheter to reinfuse the filtered blood into the vasculature of the patient.
12 . The blood filtering system of claim 1 wherein the container has a volume of 60 cubic centimeters or greater.
13 . The blood filtering system of claim 1 wherein the syringe is actuatable to draw the filtered blood along the fluid path through the filter of the filter device when the syringe is in the first state of the syringe.
14 . A system for treating clot material in the vasculature of a patient, the system comprising:
an aspiration catheter assembly including an aspiration catheter configured to be intravascularly positioned in the vasculature of the patient such that a distal end portion of the aspiration catheter is positioned proximate to the clot material;
a first container, wherein—
in a first state of the first container, the first container is attached to the aspiration catheter assembly and fluidly coupled to the aspiration catheter to receive blood and clot material aspirated from the vasculature of the patient through the aspiration catheter, and
in a second state of the second container, the second container is detached from the aspiration catheter assembly and fluidly decoupled from the aspiration catheter;
a filter device comprising:
a housing defining a chamber;
an inlet, wherein in a third state of the first container, the first container is attached to the inlet and fluidly coupled to the inlet to provide the blood and the clot material to the inlet;
an outlet;
a fluid path extending from the inlet, through the chamber, and to the outlet; and
a filter positioned in the chamber along the fluid path and configured to (a) permit the blood to flow therethrough along the fluid path from the inlet to the outlet and (b) inhibit the clot material from flowing therethrough along the fluid path from the inlet to the outlet;
a reinfusion catheter assembly including a reinfusion catheter configured to be intravascularly positioned in the vasculature of the patient; and
a second container, wherein—
in a first state of the second container, the second container is attached to the outlet and fluidly coupled to the outlet to receive filtered blood from the outlet,
in a second state of the second container, the second container is detached from the outlet and fluidly decoupled from the outlet, and
in a third state of the second container, the second container is attached to the reinfusion catheter assembly and fluidly coupled to the reinfusion catheter to reinfuse the filtered blood into the vasculature of the patient, and
the second container is configured to be in only a single one of the first state, the second state, or the third state at a time.
15 . The system of claim 14 wherein the aspiration catheter and the reinfusion catheter comprise a same catheter.
16 . The system of claim 14 wherein the second container is a syringe, and wherein the syringe is actuatable to drive the filtered blood through the reinfusion catheter when the syringe is in the third state of the syringe.
17 . The system of claim 14 wherein the second container is a syringe, and wherein the syringe is actuatable to draw the filtered blood through the outlet of the filter device when the syringe is in the first state of the syringe.
18 . A blood filtering system, comprising:
a first syringe, wherein—
in a first state of the first syringe, the first syringe is attached to an aspiration catheter assembly, fluidly coupled to an aspiration catheter of the aspiration catheter assembly, and configured to generate vacuum pressure for aspirating blood and clot material from a vasculature of a patient through the aspiration catheter and into the first syringe, and
in a second state of the first syringe, the second syringe is detached from the aspiration catheter assembly and fluidly decoupled from the aspiration catheter;
a filter device comprising:
a housing defining a chamber;
an inlet, wherein in a third state of the first syringe, the first syringe is attached to the inlet and fluidly coupled to the inlet to provide the blood and the clot material from the first syringe to the inlet;
an outlet;
a fluid path extending from the inlet, through the chamber, and to the outlet; and
a filter positioned in the chamber along the fluid path and configured to (a) permit the blood to flow therethrough along the fluid path from the inlet to the outlet and (b) inhibit the clot material from flowing therethrough along the fluid path from the inlet to the outlet; and
a second syringe, wherein—
in a first state of the second syringe, the second syringe is attached to the outlet, fluidly coupled to the outlet, and configured to generate vacuum pressure for drawing filtered blood from the outlet into the second syringe, and
in a second state of the second syringe, the second syringe is detached from the outlet and fluidly decoupled from the outlet.
19 . The blood filtering system of claim 18 wherein the first syringe is a vacuum-pressure locking syringe having a volume of 60 cubic centimeters or greater.
20 . The system of claim 14 wherein the reinfusion catheter is separate from the aspiration catheter.