Method of treating cystic fibrosis airway disease
In certain embodiments, the present invention provides a method of increasing liquid pH on airway surface of a tissue in a patient in need thereof comprising administering an effective amount of a therapeutic composition comprising tromethamine to the patient.
1 . A method of treating an airway infection in a mammal in need thereof by administering a therapeutically effective amount of a therapeutic composition consisting of tromethamine, an effective amount of hypertonic saline and an effective amount of NaHCO 3 .
2 . The method of claim 1 , wherein NaHCO 3 is present at a concentration of about 1% to about 10%.
3 . The method of claim 1 , wherein the tromethamine is at a concentration of about 0.36 g/l to about 200 g/l.
4 . The method of claim 1 , wherein the hypertonic saline comprises NaCl at a concentration of about 7%.
5 . The method of claim 1 , wherein the therapeutic composition is administered orally, by aerosol inhalation, dry powder inhalation, liquid inhalation, liquid instillation, bronchoscopic instillation, nasal lavage or sinus lavage.
6 . The method of claim 1 , wherein the tromethamine is at a concentration of 0.3 M.
7 . A method of treating an airway infection in a mammal in need thereof by administering a therapeutically effective amount of a therapeutic composition, wherein the therapeutic composition consists of tromethamine, tobramycin, and one or more agents selected from the group consisting of an effective amount of hypertonic saline and an effective amount of NaHCO 3 .
8 . The method of claim 7 , wherein the therapeutic composition consists of tromethamine, an effective amount of hypertonic saline, an effective amount of NaHCO 3 , and an effective amount of tobramycin.
9 . The method of claim 7 , wherein NaHCO 3 is present at a concentration of about 1% to about 10%.
10 . The method of claim 7 , wherein the therapeutic composition is administered orally, by aerosol inhalation, dry powder inhalation, liquid inhalation, liquid instillation, bronchoscopic instillation, nasal lavage or sinus lavage.
11 . The method of claim 7 , wherein the tromethamine is at a concentration of 0.3 M.
12 . The method of claim 7 , wherein hypertonic saline is present in the therapeutic composition, and the hypertonic saline comprises NaCl at a concentration of about 1% to about 8%.
13 . The method of claim 7 , wherein the tromethamine is at a concentration of about 0.36 g/l to about 200 g/l.