Nicotinic acid derivative A with anti-inflammation and anti-platelet aggregation activities, and use thereof
View Patent ↗The present disclosure provides a nicotinic acid derivative A with an anti-inflammation activity. The nicotinic acid derivative A has a general structural formula shown in formula (I), where R 1 and R 2 are different substitution sites of a main chain, and R 1 ′ and R 2 ′ are different substitution sites of a side chain. In the present disclosure, the nicotinic acid derivative A has desirable anti-inflammation, anti-tumor, and anti-platelet aggregation activities, and strong selectivity, and shows a remarkable clinical application value.
1 . A method for treating an autoimmune disease, comprising administrating or applying a nicotinic acid derivative A with an immunosuppressive activity to a subject in need, wherein the autoimmune disease is rheumatoid arthritis; and the nicotinic acid derivative A has a structural formula as follows: