IP Library Granted Patent US 12702664
Granted Patent B2
US 12702664 · App. 18/029,089 · Granted Aug 11, 2026

Nicotinic acid derivative A with anti-inflammation and anti-platelet aggregation activities, and use thereof

Inventors: Yong Yang (Chongqing, CN); Yanlei Guo (Chongqing, CN); Dajian Yang (Chongqing, CN)
Assignee: Chongqing Academy of Chinese Materia Medica
A61K31/455A61P7/02A61P29/00
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Quick Facts
Patent No.
US 12702664
App. No.
18/029,089
Granted
Aug 11, 2026
Kind
B2
Abstract

The present disclosure provides a nicotinic acid derivative A with an anti-inflammation activity. The nicotinic acid derivative A has a general structural formula shown in formula (I), where R 1 and R 2 are different substitution sites of a main chain, and R 1 ′ and R 2 ′ are different substitution sites of a side chain. In the present disclosure, the nicotinic acid derivative A has desirable anti-inflammation, anti-tumor, and anti-platelet aggregation activities, and strong selectivity, and shows a remarkable clinical application value.

Claims (1)

1 . A method for treating an autoimmune disease, comprising administrating or applying a nicotinic acid derivative A with an immunosuppressive activity to a subject in need, wherein the autoimmune disease is rheumatoid arthritis; and the nicotinic acid derivative A has a structural formula as follows: