Antiviral supplement formulations
The disclosure provides an oral antiviral supplement composition comprising a lysine, an ascorbic compound, a flavonoid glycoside, a threonine, and a pyridoxine. The disclosure also provides a method of reducing viral replication in a cell comprising treating a virus-infected cell with a composition of the disclosure. The disclosure further provides a method for the treatment and prophylaxis of a viral infection in a patient comprising administering a composition of the disclosure.
1 . A method of making an antiviral supplement tablet comprising mixing active ingredients including:
from about 40% to about 80% by weight of a L-lysine hydrochloride;
from about 15% to about 35% by combined weight of one or more ascorbic compounds;
from about 5% to about 20% by weight of one or more flavonoid glycosides, wherein the one or more flavonoid glycosides comprise hesperidin and rutin;
from about 0.1% to about 5% by weight of L-threonine;
from about 1% to about 10% by weight of a taurine; and
from about 0.1% to about 2% by weight of pyridoxine hydrochloride, compared to total weight of the active ingredients, with a pharmaceutically acceptable carrier to form a composition; and
forming a tablet from the composition.
2 . The method of claim 1 , wherein the forming comprises a process selected from the group consisting of wet granulation, dry granulation, and direct compression.
3 . The method of claim 1 , wherein the tablet is selected from the group consisting of orally disintegrable tablet, swallowable tablet, coated tablet, effervescent tablet, and chewable tablet.
4 . The method of claim 1 , wherein the L-lysine hydrochloride is from about 50% to about 70% by weight, compared to the total weight of the active ingredients.
5 . The method of claim 1 , wherein the L-lysine hydrochloride is selected from the group consisting of L-lysine monohydrochloride, and L-lysine dihydrochloride.
6 . The method of claim 1 , wherein combined weight of the one or more ascorbic compounds is from about 20% to about 30% by weight, compared to the total weight of the active ingredients.
7 . The method of claim 1 , wherein the one or more ascorbic compounds are selected from the group consisting of ascorbic acid, calcium ascorbate, magnesium ascorbate, potassium ascorbate, sodium ascorbate, manganese ascorbate, zinc ascorbate, iron ascorbate, copper ascorbate, boron ascorbate, molybdenum ascorbate, chromium ascorbate, ascorbyl palmitate, ascorbyl arachidonate, ascorbyl stearate, ascorbyllinoleate, ascorbyl linoleneate, and ascorbyl oleate.
8 . The method of claim 1 , wherein combined weight of the one or more flavonoid glycosides is from about 10% to about 15% by weight compared to the total weight of the active ingredients.
9 . The method of claim 1 , wherein the flavonoid glycoside comprises hesperidin and rutin in a 1:1 weight ratio.
10 . The method of claim 1 , wherein the L-threonine is from about 0.5% to about 2% by weight compared to the total weight of the active ingredients.
11 . The method of claim 1 , wherein the taurine is from about 2% to about 6% by weight compared to the total weight of the active ingredients.
12 . The method of claim 1 , wherein the pyridoxine hydrochloride is from about 0.5% to about 1.5% by weight compared to the total weight of the active ingredients.
13 . The method of claim 1 , wherein the composition includes L-lysine monohydrochloride, ascorbic acid, hesperidin, rutin, threonine, taurine, and pyridoxine hydrochloride, and optionally an additional ascorbic compound.
14 . The method of claim 13 , wherein the additional ascorbic compound is selected from the group consisting of calcium ascorbate, niacinamide ascorbate, and ascorbyl palmitate.
15 . The method of claim 1 , wherein a single dose of the antiviral supplement comprises one or more of the tablets comprising the L-lysine hydrochloride in a combined therapeutically effective amount of from about 1,000 mg to about 5,000 mg.
16 . The method of claim 15 , wherein the single dose includes from about 2 g to about 3.5 g L-lysine monohydrochloride; from about 0.1 g to about 1.5 g ascorbic acid; from about 0.2 g to about 0.8 g hesperidin; from about 0.1 g to about 0.5 g rutin; from about 0.04 g to about 0.08 g pyridoxine hydrochloride; from about 0.01 g to about 0.08 g threonine; and from about 0.02 g to about 0.4 g taurine.
17 . The method of claim 1 , wherein the composition does not include arginine.