Attenuated
Disclosed are attenuated Salmonella gallinarum expressing FliC (flagellin) or FliC-hIL2 (human IL2 fused to FliC) and use thereof, wherein the Salmonella strain exhibits excellent immune activation ability and anticancer efficacy and thus can be used as a cancer therapeutic agent, together with or independently from existing anticancer agents.
1 . A method for treating, preventing, alleviating, or inhibiting cancer, comprising administering to a subject in need thereof a pharmaceutical composition comprising as an active ingredient,
a Salmonella gallinarum strain into which a vector containing a polynucleotide encoding IL-2 (interleukin-2) fused with FliC (a filament structural protein) is introduced,
wherein the polynucleotide encoding IL-2 fused with FliC includes the sequence of SEQ ID NO: 3.