Antimicrobial therapy
This disclosure provides a synthesized version of S. felis C4 antimicrobial peptide as a topical antibiotic. S. felis C4 can be used as a probiotic strain of skin bacteria that can be transplanted onto the diseased skin of dogs, cats and dairy cows to outcompete and kill pathogenic bacteria that are causing infections such as bacterial pyoderma and mastitis.
1 . A composition comprising a peptide having the sequence of SEQ ID NO:3, or a sequence that includes 1 to 5 amino acid substitutions to SEQ ID NO:3, and at least one peptide selected from the group consisting of SEQ ID NO:4, 5 and 6, a pharmaceutically acceptable carrier for formulation as a lotion, ointment cream, powder, unguent, oil or spray, and wherein the composition inhibits or kills S. aureas and/or S. pseudintermidius.
2 . The composition of claim 1 , wherein the composition is a thickened topical formulation.
3 . The composition of claim 1 , wherein the composition is prepared for application to a surface.
4 . A method for treating skin or mucosal infection in a subject comprising contacting the subject with an effective amount of a composition of claim 1 .
5 . The method of claim 4 , wherein the skin or mucosal infection comprises an infection by S. aureas and/or S. pseudintermidius.
6 . A method of treating skin or mucosal infections in a mammal by applying to the skin or mucosa an effective amount of the composition of claim 1 to a subject in need thereof.
7 . The method according to claim 6 , wherein the composition is applied topically.
8 . A method of treating a bacterial infection in an animal or human, the method comprising exposing an infected area of the animal or human to composition of claim 1 .
9 . The method as claimed in claim 8 , wherein the bacterial infection is an infection by S. aureas and/or S. pseudintermidius.