Model predictive control in a closed loop control system for continuous glucose monitoring
A system which provides closed loop insulin administration is disclosed. A closed loop insulin administration system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.
1 . A glucose control system comprising:
a glucose sensor;
at least one medication administration system; and
one or more local hardware processors configured to execute instructions to:
determine a first connectivity state between the one or more local hardware processors and a mobile computing device;
determine a second connectivity state between the mobile computing device and one or more remote hardware processors; and
select a control process from among a plurality of control processes for operation of the at least one medication administration system based on the first connectivity state and the second connectivity state,
wherein each of the plurality of control processes determines an amount of medication to administer using a different control logic associated with a distinct combination of the first and second connectivity states, and
wherein the selection of the control process is performed as a function of the first connectivity state and second connectivity state.
2 . The glucose control system of claim 1 , wherein the first connectivity state comprises an active Bluetooth connection.
3 . The glucose control system of claim 1 , wherein the second connectivity state comprises an active internet connection.
4 . The glucose control system of claim 1 , wherein to select a control process, the one or more hardware processors are configured to:
select a first control process for operation of the at least one medication administration system if the first connectivity is an active connected state and the second connectivity is an active connected state.
5 . The glucose control system of claim 4 , wherein the first control process comprises a predictive control algorithm associated with a physiological model of a glycemic response of a user.
6 . The glucose control system of claim 5 , wherein the predictive control algorithm comprises a model predictive control algorithm.
7 . The glucose control system of claim 4 , wherein the first control process is configured to recommend medication dosage based on a glucose prediction determined using inputs comprising meal intake and medication bolus.
8 . The glucose control system of claim 4 , wherein the first control process is configured to recommend a medication dosage based on a current or predicted glucose state.
9 . The glucose control system of claim 4 , wherein the one or more hardware processors are configured to:
receive a recommended medication dosage from the one or more remote hardware processors based on inputs, the inputs comprising meal intake and medication bolus; and
output the recommended medication dosage to the at least one medication administration system.
10 . The glucose control system of claim 1 , wherein to select a control process, the one or more hardware processors are configured to:
select a second control process for operation of the at least one medication administration system if the first connectivity is an active connected state and the second connectivity is a disconnected state.
11 . The glucose control system of claim 10 , wherein the one or more hardware processors are configured to determine a recommended medication dosage based on one or more user inputs or measured glucose.
12 . The glucose control system of claim 11 , wherein the one or more user inputs comprise at least one of: meal intake, exercise, sleep, mood, or anticipated event.
13 . The glucose control system of claim 1 , wherein to select a control process, the one or more hardware processors are configured to:
select a third control process for operation of the at least one medication administration system if the first connectivity is a disconnected state and the second connectivity is a disconnected state.
14 . The glucose control system of claim 13 , wherein the third control process is configured to output a medication dosage based on a reactive glucose model.
15 . The glucose control system of claim 13 , wherein the third control process is a default operation of the medication administration system.
16 . The glucose control system of claim 13 , wherein the medication administration system comprises at least one device comprising a combination medication delivery system and glucose sensing device.
17 . The glucose control system of claim 1 , wherein the glucose sensor and the medication administration system are integrated into a single device.
18 . The glucose control system of claim 1 , wherein the one or more hardware processors are embedded in the glucose sensor.