Multi-chamber syringe
Systems and methods for multi-chambered syringes are described. In some embodiments, a multi-chamber syringe includes a housing with an internal cavity and first and second plungers disposed at least partially within the internal cavity. The first and second plungers are slidably displaceable relative to the housing, and are associated with first and second chambers respectively. A barrier is disposed at least partially between the first and second plungers to form the first and second chambers. The barrier is slidably displaceable relative to the plungers and barrel to selectively place the first and second chambers including first and second materials respectively in fluid communication. When the barrier is displaced, the first and second materials mix in a combined volume of the first and second chambers. Displacing the first plunger, the second plunger, and the barrier may dispense the mixed materials from the combined volume.
1 . A multi-chamber syringe comprising:
a housing including an internal cavity;
a first plunger disposed at least partially within the internal cavity of the housing, wherein the first plunger is slidably displaceable relative to the housing;
a second plunger disposed at least partially within the internal cavity of the housing, wherein the second plunger is slidably displaceable relative to the housing; and
a barrier disposed at least partially between the first plunger and the second plunger within the internal cavity of the housing, wherein the barrier is slidably displaceable relative to the first plunger and the second plunger, wherein the first plunger and the barrier are each configured to be independently displaceable relative to one another and the second plunger in a first mode of operation, and wherein the first plunger, the second plunger, and the barrier are configured to move in unison in a second mode of operation.
2 . The multi-chamber syringe of claim 1 , wherein the barrier is selectively engageable with the first plunger and/or the second plunger.
3 . The multi-chamber syringe of claim 1 , further comprising a first material disposed in a first chamber bounded at least in part by a first surface of the barrier and a distal surface of the first plunger.
4 . The multi-chamber syringe of claim 3 , wherein the first material comprises saline.
5 . The multi-chamber syringe of claim 1 , further comprising a second material disposed in a second chamber bounded at least in part by a second surface of the barrier and a distal surface of the second plunger.
6 . The multi-chamber syringe of claim 5 , wherein the second material comprises one or more selected from a group comprising dextran, a starch-based material, and a collagen-based material.
7 . The multi-chamber syringe of claim 1 , wherein the housing is annular, and wherein the barrier is annular.
8 . The multi-chamber syringe of claim 7 , wherein the barrier is co-axial with the housing.
9 . The multi-chamber syringe of claim 1 , wherein the first plunger is cylindrical.
10 . The multi-chamber syringe of claim 9 , wherein the barrier is annular, and wherein the barrier is co-axial with the first plunger.
11 . The multi-chamber syringe of claim 9 , wherein the second plunger is annular.
12 . The multi-chamber syringe of claim 11 , wherein the second plunger is co-axial with the first plunger.
13 . The multi-chamber syringe of claim 1 , further comprising one or more gaskets between two or more selected from the group of the first plunger, the barrier, the second plunger, and the housing.
14 . The multi-chamber syringe of claim 1 , wherein the barrier is configured to lock with the first plunger and/or the second plunger when displaced to an unsealed configuration.
15 . The multi-chamber syringe of claim 1 , further comprising one or more protrusions formed on the barrier, wherein the protrusions are configured to promote mixing.
16 . A multi-chamber syringe comprising:
a housing including an internal cavity;
a first plunger disposed at least partially within the internal cavity of the housing, wherein the first plunger is slidably displaceable relative to the housing;
a second plunger disposed at least partially within the internal cavity of the housing, wherein the second plunger is slidably displaceable relative to the housing; and
a barrier disposed at least partially between the first plunger and the second plunger within the internal cavity of the housing such that the barrier is co-axial with the first and second plungers and the second plunger is positioned radially outward relative to the barrier about a longitudinal axis of the syringe, wherein the barrier forms a first chamber bounded by at least a first surface of the barrier and a distal surface of the first plunger and a second chamber bounded by at least a second surface of the barrier and the distal surface of the second plunger, and wherein the barrier is slidably displaceable relative to the first plunger and the second plunger to facilitate mixing between volumes of the first and second chambers.
17 . The multi-chamber syringe of claim 16 , further comprising a first material disposed in the first chamber and a second material disposed in the second chamber.
18 . The multi-chamber syringe of claim 17 , wherein the first material comprises saline, and wherein the second material comprises one or more selected from a group comprising dextran, a starch-based material, and a collagen-based material.
19 . The multi-chamber syringe of claim 16 , wherein the barrier is configured to lock with the first plunger and/or the second plunger when displaced to an unsealed configuration.
20 . The multi-chamber syringe of claim 16 , wherein the housing is annular and the barrier is annular, and wherein the barrier is co-axial with the housing.
21 . A multi-chamber syringe comprising:
a housing including an internal cavity;
a first plunger disposed at least partially within the internal cavity of the housing, wherein the first plunger is slidably displaceable relative to the housing;
a second plunger disposed at least partially within the internal cavity of the housing, wherein the second plunger is slidably displaceable relative to the housing; and
a barrier disposed at least partially between the first plunger and the second plunger within the internal cavity of the housing, wherein the barrier forms a first chamber bounded by at least a first surface of the barrier and a distal surface of the first plunger and a second chamber bounded by at least a second surface of the barrier and the distal surface of the second plunger, and wherein the barrier is slidably displaceable relative to the first plunger and the second plunger to facilitate mixing between volumes of the first and second chambers, and wherein the barrier is configured to lock with the first plunger and/or the second plunger when displaced to an unsealed configuration.
22 . The multi-chamber syringe of claim 21 , further comprising a first material disposed in the first chamber and a second material disposed in the second chamber.
23 . The multi-chamber syringe of claim 22 , wherein the first material comprises saline, and wherein the second material comprises one or more selected from a group comprising dextran, a starch-based material, and a collagen-based material.
24 . The multi-chamber syringe of claim 21 , further comprising one or more protrusions formed on the barrier, wherein the protrusions are configured to promote mixing.