Drug delivery devices with reusable components and disposable components
Various exemplary drug delivery devices ( 500, 700 ) with reusable components ( 512, 702 ) and disposable components ( 504, 704, 706 ), drug products utilizing the same, and methods of using drug delivery devices with reusable components and disposable components are provided. In general, a nasal drug delivery device is configured to deliver a drug therefrom and includes one or more disposable components and one or more reusable components. The one or more disposable components are releasably coupled to the one or more reusable components. After the drug is delivered from the drug delivery device, the one or more disposable components can be detached from the one or more reusable components. Another one or more disposable components can then be releasably coupled to the one or more reusable components and the drug delivery device used to again deliver a drug therefrom.
1 . A drug delivery system, comprising:
a dispensing head including a tip configured to be positioned in a nose of a patient, the tip having an opening therein;
a drug holder containing a drug therein; and
a body including a distal coupler configured to releasably couple to a coupler of the drug holder, and the body including a proximal coupler configured to releasably couple to a coupler of the dispensing head;
wherein the drug delivery system is configured such the drug holder is not coupled to the coupler of the dispensing head while the drug is initially delivered out of the opening, and, after initiation of delivery of the drug out of the opening, the drug holder and the coupler of the dispensing head are coupled to one another such that the drug holder and dispending head are configured to be released from the proximal coupler as a unit.
2 . The system of claim 1 , wherein the drug holder is configured to be at least partially disposed within the dispensing head after the drug has been delivered out of the opening to allow the drug holder and the dispensing head to be released from the proximal coupler as the unit after the drug has been delivered out of the opening.
3 . The system of claim 1 , wherein the proximal coupler includes a thread, and the coupler of the dispensing head includes a thread configured to mate with the thread of the proximal coupler.
4 . The system of claim 1 , wherein the coupler of the dispensing head includes a clip configured to clip to the proximal coupler.
5 . The system of claim 1 , wherein one of the proximal coupler and the coupler of the dispensing head includes one or more protrusions, and the other of the proximal coupler and the coupler of the dispensing head includes one or more grooves or depressions configured to seat the one or more protrusions therein.
6 . The system of claim 1 , wherein the coupler of the dispensing head is on a distal base of the dispensing head that is configured to be manually pressed by a user to cause the drug to be delivered out of the opening.
7 . The system of claim 1 , further comprising a depth guide attached to the dispensing head configured to facilitate guiding the tip into the nose at a depth.
8 . The system of claim 1 , wherein the drug is one of ketamine, esketamine, naloxone, and sumatriptan.
9 . The system of claim 1 , further comprising:
a second dispensing head including a second tip configured to be positioned in the nose of the patient, the second tip having a second opening therein; and
a second drug holder containing a second drug therein;
wherein;
the second drug holder comprises a second coupler configured to releasably couple to the distal coupler after the drug holder and the dispensing head have been released from the proximal coupler,
a second coupler of the second dispensing head is configured to releasably couple to the proximal coupler after the drug holder and the dispensing head have been released from the proximal coupler,
the drug delivery system is configured such that the second drug holder is not coupled to the second coupler of the second dispensing head while the second drug is initially delivered out of the second opening, and, after initiation of delivery of the second drug out of the second opening, the second drug holder and the second coupler of the second dispensing head are coupled to one another such that the second drug holder and second dispensing head are configured to be released from the proximal coupler as a unit.
10 . The system of claim 9 , wherein the drug is one of ketamine, esketamine, naloxone, and sumatriptan; and
the second drug is one of ketamine, esketamine, naloxone, and sumatriptan.
11 . The system of claim 10 , wherein the drug and the second drug are the same.
12 . The system of claim 10 , wherein the drug and the second drug are different.
13 . A drug delivery method, comprising:
coupling a first dispensing head to a first coupler of a body, wherein the first dispensing head includes a coupler;
coupling a first drug holder to a second coupler of the body such that the first drug holder is not coupled to the coupler of the first dispensing head, the first drug holder containing a first drug therein;
after coupling the first dispensing head and the first drug holder to the body, causing the first drug to exit the first drug holder and spray out an opening of a tip of the first dispensing head that is positioned in a nose of a patient and causing the first drug holder and the coupler of the first dispensing head to become coupled to one another;
removing the first dispensing head and the first drug holder as a unit from the body and subsequently coupling a second dispensing head to the first coupler of the body, the second dispensing head including a coupler and coupling a second drug holder to the second coupler of the body such that the second drug holder is not coupled to the coupler of the second dispensing head, the second drug holder containing a second drug therein; and
after coupling the second dispensing head and the second drug holder to the body, causing the second drug to exit the second drug holder and spray out a second opening of a second tip of the second dispensing head that is positioned in the nose of the patient and causing the second drug holder and the coupler of the second dispensing head to become coupled to one another.
14 . The method of claim 13 , wherein the drug holder is at least partially disposed within the dispensing head after the first drug has exited the drug holder to allow the drug holder and the first dispensing head to be removed as the unit.
15 . The method of claim 13 , wherein the first coupler includes a thread, and coupling the first dispensing head to the body includes mating the first dispensing head to the thread of the first coupler.
16 . The method of claim 13 , wherein coupling the first dispensing head to the body includes clipping the first dispensing head to the first coupling-featurecoupler.
17 . The method of claim 13 , wherein the first coupler includes one or more protrusions, and coupling the first dispensing head to the body includes seating the one or more protrusions in one or more grooves or depressions of the dispensing head.
18 . The method of claim 13 , wherein the first coupler includes one or more grooves or depressions, and coupling the first dispensing head to the body includes seating one or more protrusions of the dispensing head in the one or more grooves or depressions.
19 . The method of claim 13 , wherein causing the first drug to exit the first drug holder includes pushing the first dispensing head relative to the body; and
causing the second drug to exit the second drug holder includes pushing the second dispensing head relative to the body.
20 . The method of claim 13 , wherein the first drug is one of ketamine, esketamine, naloxone, and sumatriptan; and
the second drug is one of ketamine, esketamine, naloxone, and sumatriptan.
21 . The method of claim 20 , wherein the first drug and the second drug are the same.
22 . The method of claim 20 , wherein the first drug and the second drug are different.